MTO1
Protein MTO1 homolog, mitochondrial
Protein Summary
Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000370300
- ENSP00000359323
- ENSG00000135297
- ENST00000370305
- ENSP00000359328
- ENST00000415954
- ENSP00000402038
- ENST00000498286
- ENSP00000419561
- CGI-02
- COXPD10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.85 | ||
disease perturbation | 0.74 | ||
transcription factor perturbation | 0.74 | ||
transcription factor binding site profile | 0.69 | ||
tissue sample | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 113.2 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 85 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 113.2 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 85 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0