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Tbio
SUGT1
Protein SGT1 homolog

Protein Summary
Description
May play a role in ubiquitination and subsequent proteasomal degradation of target proteins. This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310528
  • ENSP00000308067
  • ENSG00000165416
  • ENST00000343788
  • ENSP00000367208

Symbol
  • SGT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
interacting protein
0.95
disease perturbation
0.93
histone modification site profile
0.9
transcription factor binding site profile
0.88


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.02   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.02   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
VGNC:7304
452744
Macaque
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
694046
Mouse
MGI:1915205
67955
Rat
RGD:1307550
290408
Horse
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
VGNC:23752
100051549
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
Macaque
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
Mouse
Rat
Horse
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y2Z0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Inflammasomes
Reactome
Innate Immune System
Reactome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Reactome
The NLRP3 inflammasome
Name
Explore in Pharos
Explore in Source
Immune System
Inflammasomes
Innate Immune System
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
The NLRP3 inflammasome
Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (162)
1 – 10 of 162
LRRC39
Tdark
Novelty:  0.70657884
p_int:  0.999893469
p_ni:  0.000106531
Score:  0.237
Data Source:  BioPlex,STRINGDB
TTC9C
Tdark
Novelty:  0.85949913
p_int:  0.999005447
p_ni:  0.000994554
Data Source:  BioPlex
LRRC57
Tdark
Novelty:  5.85929893
p_int:  0.992573163
p_ni:  0.007426837
Score:  0.26
Data Source:  BioPlex,STRINGDB
FBXL14
Tbio
Novelty:  0.21211079
p_int:  0.986412297
p_ni:  0.013587703
Score:  0.179
Data Source:  BioPlex,STRINGDB
SKP2
Tbio
Family:  Enzyme
Novelty:  0.00182658
p_int:  0.984696032
p_ni:  0.015303968
Score:  0.152
Data Source:  BioPlex,STRINGDB
LRCH1
Tbio
Novelty:  0.0923291
p_int:  0.981794933
p_ni:  0.018205068
Data Source:  BioPlex
LRRC20
Tdark
Novelty:  3.82267008
p_int:  0.976635036
p_ni:  0.023364965
Data Source:  BioPlex
ALDH1L2
Tbio
Family:  Enzyme
Novelty:  0.05452547
p_int:  0.967196497
p_ni:  0.032803503
Score:  0.203
Data Source:  BioPlex,STRINGDB
MRPS25
Tdark
Novelty:  0.59354314
p_int:  0.963768992
p_ni:  0.036231008
Data Source:  BioPlex
AURKB
Tchem
Family:  Kinase
Novelty:  0.00100972
p_int:  0.960758497
p_ni:  0.039241503
Score:  0.28
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  13.02

PubMed score by year
PubTator Score  40.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer