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Tbio
KLF13
Krueppel-like factor 13

Protein Summary
Description
Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells. KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307145
  • ENSP00000302456
  • ENSG00000169926

Symbol
  • BTEB3
  • NSLP1
  • BTEB3
  • FKLF2
  • NSLP1
  • RFLAT1
  • RFLAT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor binding site profile
0.88
transcription factor
0.79
gene perturbation
0.74
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.89   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.89   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
CHCHD10
Tbio
Novelty:  0.01659548
p_int:  0.999476062
p_ni:  1.1e-8
p_wrong:  0.000523927
Score:  0.345
Data Source:  BioPlex,STRINGDB
MTMR10
Tdark
Novelty:  0.24626422
Score:  0.75
Data Source:  STRINGDB
GYPB
Tbio
Novelty:  0.00442195
Score:  0.71
Data Source:  STRINGDB
GATA4
Tbio
Family:  TF
Novelty:  0.00094282
Score:  0.684
Data Source:  STRINGDB
CCL5
Tchem
Novelty:  0.00032607
Score:  0.67
Data Source:  STRINGDB
OTUD7A
Tbio
Novelty:  0.09531354
Score:  0.663
Data Source:  STRINGDB
CHRNA7
Tchem
Family:  IC
Novelty:  0.00590784
Score:  0.654
Data Source:  STRINGDB
SIN3A
Tbio
Novelty:  0.00747207
Score:  0.633
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.593
Data Source:  STRINGDB
TRPM1
Tchem
Family:  IC
Novelty:  0.00822899
Score:  0.56
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
9
5
12
91.8
red blood cell distribution width
4
3
5
90.2
mean corpuscular volume
3
4
4
86.2
hip circumference
2
5
5
81.1
waist-hip ratio
4
6
7
70.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
12
91.8
red blood cell distribution width
5
90.2
mean corpuscular volume
4
86.2
hip circumference
5
81.1
waist-hip ratio
7
70.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1354948
50794
Pig
Kruppel like factor 13
494563
Opossum
Kruppel like factor 13
100016048
Xenopus
Kruppel-like factor 13
XB-GENE-479837
100101699
Zebrafish
ZDB-GENE-060929-1274
767805
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Pig
Kruppel like factor 13
Opossum
Kruppel like factor 13
Xenopus
Kruppel-like factor 13
Zebrafish
Publication Statistics
PubMed Score 52.89
PubMed score by year
PubTator Score 23.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title