Tbio PRG3 Proteoglycan 3

Protein Summary

Description

Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils.

Uniprot Accession IDs

• Q9Y2Y8

Gene Name

• PRG3

Ensembl ID

• ENST00000287143
• ENSP00000287143
• ENSG00000156575

Symbol

• MBPH
• MBP2
• MBPH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.92
biological process	0.79
protein domain	0.73
tissue	0.48
cell line	0.46

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Extracellular Matrix Structural Protein / Proteoglycan 3

Protein / Defense/immunity Protein / Antibacterial Response Protein / Proteoglycan 3

Protein / ... / Protease Inhibitor / Proteoglycan 3

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Proteoglycan 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.56   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 33   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.56   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0