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Tbio
ZBTB32
Zinc finger and BTB domain-containing protein 32

Protein Summary
Description
DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262630
  • ENSP00000262630
  • ENSG00000011590
  • ENST00000392197
  • ENSP00000376035

Symbol
  • FAZF
  • TZFP
  • ZNF538
  • Rog
  • FAXF
  • FAZF
  • TZFP
  • ZNF538
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological process
0.74
cell type or tissue
0.65
tissue sample
0.62
transcription factor
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.56   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.56   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
64.9
self reported educational attainment
1
1
1
46.1
mathematical ability
1
1
1
38.8
eosinophil percentage of leukocytes
1
1
1
37.6
age at first sexual intercourse measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
64.9
self reported educational attainment
1
46.1
mathematical ability
1
38.8
eosinophil percentage of leukocytes
1
37.6
age at first sexual intercourse measurement
1
33.1
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 32
VGNC:11461
745538
Macaque
zinc finger and BTB domain containing 32
710216
Mouse
MGI:1891838
58206
Rat
RGD:1584121
688845
Horse
zinc finger and BTB domain containing 32
VGNC:25143
100059770
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 32
Macaque
zinc finger and BTB domain containing 32
Mouse
Rat
Horse
zinc finger and BTB domain containing 32
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y2Y4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (25)
1 – 10 of 25
WDR48
Tbio
Novelty:  0.04070481
Score:  0.905
Data Source:  STRINGDB
USP1
Tchem
Family:  Enzyme
Novelty:  0.0092606
Score:  0.902
Data Source:  STRINGDB
GATA3
Tbio
Family:  TF
Novelty:  0.00071141
Score:  0.728
Data Source:  STRINGDB
FUT7
Tchem
Family:  Enzyme
Novelty:  0.01257357
Score:  0.719
Data Source:  STRINGDB
PRDM1
Tbio
Family:  TF; Epigenetic
Novelty:  0.00224931
Score:  0.625
Data Source:  STRINGDB
HDAC3
Tclin
Family:  Epigenetic
Novelty:  0.00393172
Score:  0.604
Data Source:  STRINGDB
HDAC5
Tclin
Family:  Epigenetic
Novelty:  0.00484422
Score:  0.601
Data Source:  STRINGDB
KMT2B
Tbio
Family:  Epigenetic
Novelty:  0.00593529
Score:  0.587
Data Source:  STRINGDB
TXK
Tchem
Family:  Kinase
Novelty:  0.00278405
Score:  0.552
Data Source:  STRINGDB
FANCC
Tbio
Novelty:  0.00546581
Score:  0.546
Data Source:  STRINGDB
Publication Statistics
PubMed Score  22.56

PubMed score by year
PubTator Score  10.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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