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Tbio
ZBTB32
Zinc finger and BTB domain-containing protein 32

Protein Summary
Description
DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262630
  • ENSP00000262630
  • ENSG00000011590
  • ENST00000392197
  • ENSP00000376035

Symbol
  • FAZF
  • TZFP
  • ZNF538
  • Rog
  • FAXF
  • FAZF
  • TZFP
  • ZNF538
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological process
0.74
cell type or tissue
0.65
tissue sample
0.62
transcription factor
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.83   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.83   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (25)
1 – 10 of 25
WDR48
Tbio
Novelty: 0.04070481
Score: 0.905
Data Source: STRINGDB
USP1
Tchem
Family: Enzyme
Novelty: 0.0092606
Score: 0.902
Data Source: STRINGDB
GATA3
Tbio
Family: TF
Novelty: 0.00071141
Score: 0.728
Data Source: STRINGDB
FUT7
Tchem
Family: Enzyme
Novelty: 0.01257357
Score: 0.719
Data Source: STRINGDB
PRDM1
Tbio
Family: TF; Epigenetic
Novelty: 0.00224931
Score: 0.625
Data Source: STRINGDB
HDAC3
Tclin
Family: Epigenetic
Novelty: 0.00393172
Score: 0.604
Data Source: STRINGDB
HDAC5
Tclin
Family: Epigenetic
Novelty: 0.00484422
Score: 0.601
Data Source: STRINGDB
KMT2B
Tbio
Family: Epigenetic
Novelty: 0.00593529
Score: 0.587
Data Source: STRINGDB
TXK
Tchem
Family: Kinase
Novelty: 0.00278405
Score: 0.552
Data Source: STRINGDB
FANCC
Tbio
Novelty: 0.00546581
Score: 0.546
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.83

PubMed score by year
PubTator Score  10.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer