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Tbio
ARL2BP
ADP-ribosylation factor-like protein 2-binding protein

Protein Summary
Description
Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219204
  • ENSP00000219204
  • ENSG00000102931

Symbol
  • BART
  • BART1
  • BART
  • RP66
  • BART1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
histone modification site profile
0.83
virus perturbation
0.76
tissue sample
0.72
cellular component
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.35   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.35   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
3
3
94.8
apolipoprotein A 1 measurement
2
2
2
90.2
hematocrit
2
2
2
62.6
mean corpuscular hemoglobin concentration
2
2
2
57.1
hemoglobin measurement
2
2
2
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
94.8
apolipoprotein A 1 measurement
2
90.2
hematocrit
2
62.6
mean corpuscular hemoglobin concentration
2
57.1
hemoglobin measurement
2
52
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 2 binding protein
VGNC:5676
736837
Mouse
MGI:1349429
107566
Rat
RGD:1561471
498910
Dog
ADP ribosylation factor like GTPase 2 binding protein
VGNC:38110
611248
Horse
ADP ribosylation factor like GTPase 2 binding protein
100062265
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 2 binding protein
Mouse
Rat
Dog
ADP ribosylation factor like GTPase 2 binding protein
Horse
ADP ribosylation factor like GTPase 2 binding protein
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y2Y0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Reactome
Transport of small molecules
Reactome
Transport of vitamins, nucleosides, and related molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Transport of small molecules
Transport of vitamins, nucleosides, and related molecules
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (57)
1 – 10 of 57
ELF2
Tbio
Family:  TF
Novelty:  0.01302604
p_int:  0.999998377
p_ni:  0.000001623
Data Source:  BioPlex
ARL2
Tbio
Family:  Enzyme
Novelty:  0.01989908
p_int:  0.999997653
p_ni:  0.000002346
p_wrong:  2e-9
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
ELF1
Tbio
Family:  TF
Novelty:  0.10888716
p_int:  0.999992403
p_ni:  4.5e-8
p_wrong:  0.000007552
Data Source:  BioPlex
POGK
Tbio
Novelty:  0.17276635
p_int:  0.999911936
p_ni:  0.000058213
p_wrong:  0.000029851
Data Source:  BioPlex
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.99989952
p_ni:  0.000091819
p_wrong:  0.000008662
Data Source:  BioPlex
ATE1
Tbio
Family:  Enzyme
Novelty:  0.01672896
p_int:  0.999330239
p_ni:  0.000669761
Data Source:  BioPlex
UBB
Tbio
Novelty:  0.00661254
p_int:  0.99722653
p_ni:  0.002758747
p_wrong:  0.000014723
Data Source:  BioPlex
SPINDOC
Tdark
Novelty:  0.70981211
p_int:  0.985458613
p_ni:  0.014529737
p_wrong:  0.000011651
Data Source:  BioPlex
CFAP20
Tbio
Novelty:  0.01299681
p_int:  0.985069614
p_ni:  0.014930385
p_wrong:  1e-9
Score:  0.229
Data Source:  BioPlex,STRINGDB
ECPAS
Tbio
Novelty:  0.04004664
p_int:  0.98299602
p_ni:  0.01700398
Data Source:  BioPlex
Publication Statistics
PubMed Score  34.35

PubMed score by year
PubTator Score  413.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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