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Tbio
ZNF281
Zinc finger protein 281

Protein Summary
Description
Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294740
  • ENSP00000294740
  • ENSG00000162702
  • ENST00000367352
  • ENSP00000356321
  • ENST00000367353
  • ENSP00000356322

Symbol
  • GZP1
  • ZBP99
  • ZBP-99
  • ZNP-99
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
transcription factor perturbation
0.84
transcription factor binding site profile
0.8
disease perturbation
0.79
kinase perturbation
0.76


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.6   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.6   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 281
709466
Mouse
MGI:3029290
226442
Rat
RGD:1305139
305083
Horse
zinc finger protein 281
VGNC:25294
102150335
Opossum
zinc finger protein 281 [Source:HGNC Symbol;Acc:HGNC:13075]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 281
Mouse
Rat
Horse
zinc finger protein 281
Opossum
zinc finger protein 281 [Source:HGNC Symbol;Acc:HGNC:13075]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y2X9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Endoderm Differentiation
WikiPathways
Hippo-Yap signaling pathway
WikiPathways
Hippo-Merlin Signaling Dysregulation
Name
Explore in Pharos
Explore in Source
Mesodermal Commitment Pathway
Mesodermal Commitment Pathway
Endoderm Differentiation
Hippo-Yap signaling pathway
Hippo-Merlin Signaling Dysregulation
Gene Ontology Terms (19)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (40)
1 – 10 of 40
LPXN
Tbio
Novelty: 0.00796678
p_int: 0.994295467
p_ni: 0.005704533
Score: 0.182
Data Source: BioPlex,STRINGDB
L3MBTL1
Tchem
Family: TF; Epigenetic
Novelty: 0.02321712
p_int: 0.974101626
p_ni: 0.025898374
Score: 0.227
Data Source: BioPlex,STRINGDB
DRC3
Tdark
Novelty: 0.99283468
p_int: 0.91778899
p_ni: 0.08221101
Data Source: BioPlex
CDC16
Tbio
Novelty: 0.00916715
p_int: 0.900628479
p_ni: 0.099371521
Score: 0.165
Data Source: BioPlex,STRINGDB
MGARP
Tbio
Novelty: 0.02883753
p_int: 0.877130758
p_ni: 0.122869242
Data Source: BioPlex
C6orf141
Tdark
Novelty: 1.46022784
p_int: 0.864152603
p_ni: 0.135847397
Data Source: BioPlex
ABTB2
Tdark
Novelty: 0.45729157
p_int: 0.825199666
p_ni: 0.174800334
Data Source: BioPlex
POU5F1
Tbio
Family: TF
Novelty: 0.00033974
Score: 0.67
Data Source: STRINGDB
NANOG
Tbio
Family: TF
Novelty: 0.00054893
Score: 0.656
Data Source: STRINGDB
SOX2
Tbio
Family: TF
Novelty: 0.00037089
Score: 0.6
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.60

PubMed score by year
PubTator Score  4.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer