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Tbio
UBE2D4
Ubiquitin-conjugating enzyme E2 D4

Protein Classes
Protein Summary
Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222402
  • ENSP00000222402
  • ENSG00000078967

Symbol
  • UBCH5D
  • HBUCE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
molecular function
0.91
virus perturbation
0.83
histone modification site profile
0.82
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.51   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.51   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (9)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Protein-Protein Interactions (317)
1 – 10 of 317
URGCP
Tbio
Novelty: 0.05299371
p_int: 0.999999944
p_ni: 5.6e-8
Data Source: BioPlex
TRIP12
Tbio
Family: Enzyme
Novelty: 0.00653395
p_int: 0.999999835
p_ni: 1.66e-7
Score: 0.965
Data Source: BioPlex,STRINGDB
RNF10
Tbio
Novelty: 0.12240086
p_int: 0.999999268
p_ni: 7.23e-7
p_wrong: 9e-9
Score: 0.215
Data Source: BioPlex,STRINGDB
RNF25
Tbio
Family: Enzyme
Novelty: 0.00264841
p_int: 0.999998374
p_ni: 3.52e-7
p_wrong: 0.000001275
Score: 0.947
Data Source: BioPlex,STRINGDB
UBB
Tbio
Novelty: 0.00895161
p_int: 0.99953153
p_ni: 0.000466827
p_wrong: 0.000001644
Score: 0.978
Data Source: BioPlex,STRINGDB
OTUB1
Tbio
Family: Enzyme
Novelty: 0.01650041
p_int: 0.999345682
p_ni: 0.000654318
Score: 0.582
Data Source: BioPlex,STRINGDB
HECTD1
Tbio
Family: Enzyme
Novelty: 0.36734694
p_int: 0.996534191
p_ni: 0.003465809
Score: 0.924
Data Source: BioPlex,STRINGDB
UBAC1
Tbio
Novelty: 0.00195339
p_int: 0.835041211
p_ni: 0.164950411
p_wrong: 0.000008378
Score: 0.916
Data Source: BioPlex,STRINGDB
UHRF1
Tbio
Family: Epigenetic
Novelty: 0.00590203
p_int: 0.78432498
p_ni: 0.215673663
p_wrong: 0.000001358
Data Source: BioPlex
UBA1
Tbio
Novelty: 0.00582285
Score: 0.984
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.51

PubMed score by year
PubTator Score  1.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer