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Tbio
GIT1
ARF GTPase-activating protein GIT1

Protein Summary
Description
GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve ENTR1 and PTPN13 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225394
  • ENSP00000225394
  • ENSG00000108262
  • ENST00000394869
  • ENSP00000378338
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.85
small molecule perturbation
0.75
transcription factor binding site profile
0.74
protein domain
0.73
transcription factor
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.95   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 441   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.95   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 441   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
1
3.3
94
mean platelet volume
1
1
1
87.7
heel bone mineral density
2
1
2
82.5
lymphocyte count
2
2
2
82.4
BMI-adjusted waist-hip ratio
2
2
3
74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
3.3
94
mean platelet volume
1
87.7
heel bone mineral density
2
82.5
lymphocyte count
2
82.4
BMI-adjusted waist-hip ratio
3
74
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GIT ArfGAP 1
VGNC:9301
454549
Macaque
GIT ArfGAP 1
716944
Mouse
MGI:1927140
216963
Rat
RGD:69331
83709
Dog
GIT ArfGAP 1
VGNC:41229
491180
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GIT ArfGAP 1
Macaque
GIT ArfGAP 1
Mouse
Rat
Dog
GIT ArfGAP 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y2X7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (154)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of RAC1 downstream of NMDARs
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Activation of RAC1 downstream of NMDARs
Axon guidance
Developmental Biology
EPH-Ephrin signaling
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (136)
1 – 10 of 136
ARHGEF6
Tbio
Novelty:  0.02162737
p_int:  0.999999994
p_ni:  6e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999999428
p_ni:  5.72e-7
Score:  0.962
Data Source:  BioPlex,Reactome,STRINGDB
ARHGEF7
Tbio
Novelty:  0.00919946
p_int:  0.999999013
p_ni:  9.88e-7
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
LPXN
Tbio
Novelty:  0.00796678
p_int:  0.999996716
p_ni:  0.000003284
Score:  0.452
Data Source:  BioPlex,STRINGDB
TAX1BP3
Tbio
Novelty:  0.01605171
p_int:  0.999994598
p_ni:  0.000005402
Data Source:  BioPlex
NCKIPSD
Tbio
Novelty:  0.07453111
p_int:  0.999985358
p_ni:  0.000014642
Score:  0.607
Data Source:  BioPlex,STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.999961832
p_ni:  0.000038168
Data Source:  BioPlex
ICAM1
Tchem
Novelty:  0.00009746
p_int:  0.999938179
p_ni:  0.000061821
Score:  0.473
Data Source:  BioPlex,STRINGDB
FBXO28
Tbio
Novelty:  0.10548865
p_int:  0.999927121
p_ni:  0.000072877
p_wrong:  1e-9
Score:  0.345
Data Source:  BioPlex,STRINGDB
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.99991161
p_ni:  0.00008839
Score:  0.966
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  119.95

PubMed score by year
PubTator Score  144.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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