Tbio MED16 Mediator of RNA polymerase II transcription subunit 16

Protein Summary

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Uniprot Accession IDs

• Q9Y2X0
• Q6PJT2
• Q96AD4
• Q96I35
• Q9Y652

Gene Name

• MED16

Ensembl ID

• ENST00000312090
• ENSP00000308528
• ENSG00000175221
• ENST00000325464
• ENSP00000325612
• ENST00000395808
• ENSP00000379153
• ENST00000589119
• ENSP00000464810

Symbol

• DRIP92
• THRAP5
• DRIP92
• THRAP5
• TRAP95

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.84
transcription factor perturbation	0.84
molecular function	0.76
protein domain	0.73
protein complex	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.73   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.73   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0