Protein Classes
Protein Summary
Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation. This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are inte ...more
- ENST00000295225
- ENSP00000295225
- ENSG00000115041
- ENST00000468529
- ENSP00000417499
- CSEN
- DREAM
- KCHIP3
- CSEN
- DREAM
- KCHIP3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.99 | ||
biological process | 0.85 | ||
cellular component | 0.73 | ||
microRNA | 0.58 | ||
protein domain | 0.58 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.17 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 464 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.17 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 464 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | potassium voltage-gated channel interacting protein 3 | VGNC:276 | 459401 | |||||
Macaque | potassium voltage-gated channel interacting protein 3 | 704307 | ||||||
Mouse | MGI:1929258 | 56461 | ||||||
Rat | RGD:70888 | 65199 | ||||||
Dog | potassium voltage-gated channel interacting protein 3 | VGNC:42256 | 100856050 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | potassium voltage-gated channel interacting protein 3 | |||||
Macaque | potassium voltage-gated channel interacting protein 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | potassium voltage-gated channel interacting protein 3 | |||||
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (118)
Reactome (3)
PathwayCommons (2)
WikiPathways (113)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cardiac conduction | ||||
Reactome | Muscle contraction | ||||
Reactome | Phase 1 - inactivation of fast Na+ channels | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cardiac conduction | ||||
Muscle contraction | ||||
Phase 1 - inactivation of fast Na+ channels | ||||
Gene Ontology Terms (24)
Functions (9)
Components (9)
Processes (6)
Items per page:
10
1 – 9 of 9
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (88)
1 – 10 of 88
KCND2
Family: IC
Novelty: 0.00297203
Score: 0.994
Data Source: Reactome,STRINGDB
KCND3
Family: IC
Novelty: 0.00328276
Score: 0.978
Data Source: Reactome,STRINGDB
KCND1
Family: IC
Novelty: 0.03738277
Score: 0.972
Data Source: Reactome,STRINGDB
CREM
Family: TF
Novelty: 0.00331358
Score: 0.947
Data Source: STRINGDB
KCNC1
Family: IC
Novelty: 0.00252943
Score: 0.807
Data Source: STRINGDB
PSEN1
Family: Enzyme
Novelty: 0.00024189
Score: 0.789
Data Source: STRINGDB
CLN3
Novelty: 0.00242393
Score: 0.767
Data Source: STRINGDB
TEAD3
Family: TF
Novelty: 0.04014337
Score: 0.762
Data Source: STRINGDB
KCNA4
Family: IC
Novelty: 0.00362065
Score: 0.732
Data Source: STRINGDB
SOD3
Family: Enzyme
Novelty: 0.0015758
Score: 0.724
Data Source: STRINGDB
Publication Statistics
PubMed Score 76.17
PubMed score by year
PubTator Score 1143.17
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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