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Tbio
KCNIP3
Calsenilin

Protein Classes
Protein Summary
Description
Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation. This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are inte ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295225
  • ENSP00000295225
  • ENSG00000115041
  • ENST00000468529
  • ENSP00000417499

Symbol
  • CSEN
  • DREAM
  • KCHIP3
  • CSEN
  • DREAM
  • KCHIP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
biological process
0.85
cellular component
0.73
microRNA
0.58
protein domain
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.17   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 464   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.17   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 464   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel interacting protein 3
VGNC:276
459401
Macaque
potassium voltage-gated channel interacting protein 3
704307
Mouse
MGI:1929258
56461
Rat
RGD:70888
65199
Dog
potassium voltage-gated channel interacting protein 3
VGNC:42256
100856050
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel interacting protein 3
Macaque
potassium voltage-gated channel interacting protein 3
Mouse
Rat
Dog
potassium voltage-gated channel interacting protein 3
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (118)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 1 - inactivation of fast Na+ channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 1 - inactivation of fast Na+ channels
Gene Ontology Terms (24)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (88)
1 – 10 of 88
KCND2
Tclin
Family: IC
Novelty: 0.00297203
Score: 0.994
Data Source: Reactome,STRINGDB
KCND3
Tclin
Family: IC
Novelty: 0.00328276
Score: 0.978
Data Source: Reactome,STRINGDB
KCND1
Tclin
Family: IC
Novelty: 0.03738277
Score: 0.972
Data Source: Reactome,STRINGDB
CREM
Tbio
Family: TF
Novelty: 0.00331358
Score: 0.947
Data Source: STRINGDB
KCNC1
Tclin
Family: IC
Novelty: 0.00252943
Score: 0.807
Data Source: STRINGDB
PSEN1
Tchem
Family: Enzyme
Novelty: 0.00024189
Score: 0.789
Data Source: STRINGDB
CLN3
Tbio
Novelty: 0.00242393
Score: 0.767
Data Source: STRINGDB
TEAD3
Tbio
Family: TF
Novelty: 0.04014337
Score: 0.762
Data Source: STRINGDB
KCNA4
Tclin
Family: IC
Novelty: 0.00362065
Score: 0.732
Data Source: STRINGDB
SOD3
Tbio
Family: Enzyme
Novelty: 0.0015758
Score: 0.724
Data Source: STRINGDB
Publication Statistics
PubMed Score  76.17

PubMed score by year
PubTator Score  1143.17

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer