Tbio WBP11 WW domain-binding protein 11

Protein Summary

Description

Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y2W2
• Q96AY8
• WBP-11

Gene Name

• WBP11

Ensembl ID

• ENST00000261167
• ENSP00000261167
• ENSG00000084463

Symbol

• NPWBP
• SIPP1
• SNP70
• NPWBP
• SIPP1
• WBP-11
• PPP1R165

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
ligand (protein) perturbation	0.83
transcription factor perturbation	0.8
transcription factor binding site profile	0.69
kinase perturbation	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.1   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 87   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.1   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0