WBP11
WW domain-binding protein 11
Protein Summary
Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus. [provided by RefSeq, Jul 2008]
- ENST00000261167
- ENSP00000261167
- ENSG00000084463
- NPWBP
- SIPP1
- SNP70
- NPWBP
- SIPP1
- WBP-11
- PPP1R165
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.91 | ||
ligand (protein) perturbation | 0.83 | ||
transcription factor perturbation | 0.8 | ||
transcription factor binding site profile | 0.69 | ||
kinase perturbation | 0.66 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15.08 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 87 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15.08 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 87 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of RNA | ||||
Reactome | Processing of Capped Intron-Containing Pre-mRNA | ||||
Reactome | mRNA Splicing | ||||
Reactome | mRNA Splicing - Major Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of RNA | ||||
Processing of Capped Intron-Containing Pre-mRNA | ||||
mRNA Splicing | ||||
mRNA Splicing - Major Pathway | ||||
Gene Ontology Terms (10)
Functions (3)
Components (4)
Processes (3)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (215)
1 – 10 of 215
PPP1CA
Family: Enzyme
Novelty: 0.00685545
p_int: 0.999998882
p_ni: 0.000001118
Score: 0.715
Data Source: BioPlex,STRINGDB
C5orf22
Novelty: 4
p_int: 0.999993444
p_ni: 0.000006556
Score: 0.332
Data Source: BioPlex,STRINGDB
PPP1CC
Family: Enzyme
Novelty: 0.00538884
p_int: 0.999992141
p_ni: 0.000007859
Score: 0.587
Data Source: BioPlex,STRINGDB
SNRPC
Novelty: 0.03157727
p_int: 0.999449851
p_ni: 0.000545114
p_wrong: 0.000005035
Score: 0.931
Data Source: BioPlex,STRINGDB
PQBP1
Novelty: 0.0195288
p_int: 0.999274662
p_ni: 0.000725337
p_wrong: 1e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
JPH4
Novelty: 0.02095843
p_int: 0.998404612
p_ni: 0.000575607
p_wrong: 0.001019781
Data Source: BioPlex
HSD3B2
Family: Enzyme
Novelty: 0.00875526
p_int: 0.995084434
p_ni: 0.004884971
p_wrong: 0.000030595
Score: 0.165
Data Source: BioPlex,STRINGDB
ID2
Family: TF
Novelty: 0.00329378
p_int: 0.994659898
p_ni: 0.005323416
p_wrong: 0.000016686
Score: 0.177
Data Source: BioPlex,STRINGDB
RBM5
Novelty: 0.02004452
Score: 0.972
Data Source: STRINGDB
SF3A2
Novelty: 0.04447104
Score: 0.972
Data Source: STRINGDB
Publication Statistics
PubMed Score 15.08
PubMed score by year
PubTator Score 6.87
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: