WBP11
WW domain-binding protein 11
Protein Summary
Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus. [provided by RefSeq, Jul 2008]
- ENST00000261167
- ENSP00000261167
- ENSG00000084463
- NPWBP
- SIPP1
- SNP70
- NPWBP
- SIPP1
- WBP-11
- PPP1R165
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.91 | ||
ligand (protein) perturbation | 0.83 | ||
transcription factor perturbation | 0.8 | ||
transcription factor binding site profile | 0.69 | ||
kinase perturbation | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.1 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 87 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.1 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 87 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0