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Tbio
WBP11
WW domain-binding protein 11

Protein Summary
Description
Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261167
  • ENSP00000261167
  • ENSG00000084463

Symbol
  • NPWBP
  • SIPP1
  • SNP70
  • NPWBP
  • SIPP1
  • WBP-11
  • PPP1R165
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
ligand (protein) perturbation
0.83
transcription factor perturbation
0.8
transcription factor binding site profile
0.69
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.08   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.08   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (215)
1 – 10 of 215
PPP1CA
Tchem
Family: Enzyme
Novelty: 0.00685545
p_int: 0.999998882
p_ni: 0.000001118
Score: 0.715
Data Source: BioPlex,STRINGDB
C5orf22
Tdark
Novelty: 4
p_int: 0.999993444
p_ni: 0.000006556
Score: 0.332
Data Source: BioPlex,STRINGDB
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00538884
p_int: 0.999992141
p_ni: 0.000007859
Score: 0.587
Data Source: BioPlex,STRINGDB
SNRPC
Tbio
Novelty: 0.03157727
p_int: 0.999449851
p_ni: 0.000545114
p_wrong: 0.000005035
Score: 0.931
Data Source: BioPlex,STRINGDB
PQBP1
Tbio
Novelty: 0.0195288
p_int: 0.999274662
p_ni: 0.000725337
p_wrong: 1e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
JPH4
Tbio
Novelty: 0.02095843
p_int: 0.998404612
p_ni: 0.000575607
p_wrong: 0.001019781
Data Source: BioPlex
HSD3B2
Tclin
Family: Enzyme
Novelty: 0.00875526
p_int: 0.995084434
p_ni: 0.004884971
p_wrong: 0.000030595
Score: 0.165
Data Source: BioPlex,STRINGDB
ID2
Tbio
Family: TF
Novelty: 0.00329378
p_int: 0.994659898
p_ni: 0.005323416
p_wrong: 0.000016686
Score: 0.177
Data Source: BioPlex,STRINGDB
RBM5
Tbio
Novelty: 0.02004452
Score: 0.972
Data Source: STRINGDB
SF3A2
Tbio
Novelty: 0.04447104
Score: 0.972
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.08

PubMed score by year
PubTator Score  6.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer