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Tbio
THRAP3
Thyroid hormone receptor-associated protein 3

Protein Summary
Description
Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Media ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354618
  • ENSP00000346634
  • ENSG00000054118
  • ENST00000469141
  • ENSP00000433825

Symbol
  • BCLAF2
  • TRAP150
  • BCLAF2
  • TRAP150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
1
drug perturbation
0.99
hub protein
0.97
virus perturbation
0.97


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.69   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.69   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (166)
ERH
Tbio
Novelty:  0.00711649
p_int:  0.999358271
p_ni:  0.000641729
Data Source:  BioPlex
PNN
Tbio
Novelty:  0.01395394
p_int:  0.993589846
p_ni:  0.006410154
Score:  0.807
Data Source:  BioPlex,STRINGDB
PRMT8
Tchem
Family:  Epigenetic
Novelty:  0.04213384
p_int:  0.990890281
p_ni:  0.009109719
Data Source:  BioPlex
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.990418491
p_ni:  0.009581509
Score:  0.27
Data Source:  BioPlex,STRINGDB
SNIP1
Tbio
Novelty:  0.01865867
p_int:  0.987493712
p_ni:  0.012506287
Score:  0.694
Data Source:  BioPlex,STRINGDB
LUC7L2
Tdark
Novelty:  0.36989457
p_int:  0.976760647
p_ni:  0.023239353
Data Source:  BioPlex
TNFRSF13B
Tbio
Novelty:  0.00338954
p_int:  0.968664337
p_ni:  0.031335662
p_wrong:  1e-9
Data Source:  BioPlex
NKAPD1
Tdark
Novelty:  1.56979675
p_int:  0.959158859
p_ni:  0.040841141
Data Source:  BioPlex
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.958701742
p_ni:  0.041298258
Data Source:  BioPlex
CHCHD10
Tbio
Novelty:  0.01659548
p_int:  0.946538207
p_ni:  0.053461793
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (358)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Reactome
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Name
Explore in Pharos
Explore in Source
Developmental Biology
Metabolism
Metabolism of lipids
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
2
3
74
reticulocyte count
2
1
2
63.7
platelet crit
1
1
1
53.3
platelet count
1
1
1
45.7
neutrophil count
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
74
reticulocyte count
2
63.7
platelet crit
1
53.3
platelet count
1
45.7
neutrophil count
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thyroid hormone receptor associated protein 3
VGNC:1673
456752
Macaque
thyroid hormone receptor associated protein 3
713033
Mouse
MGI:2442637
230753
Rat
RGD:1306129
313591
Dog
thyroid hormone receptor associated protein 3
VGNC:47354
482476
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thyroid hormone receptor associated protein 3
Macaque
thyroid hormone receptor associated protein 3
Mouse
Rat
Dog
thyroid hormone receptor associated protein 3
Publication Statistics
PubMed Score 14.69
PubMed score by year
PubTator Score 9.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title