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Tbio
COG6
Conserved oligomeric Golgi complex subunit 6

Protein Summary
Description
Required for normal Golgi function. This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi apparatus. The encoded protein is organized with conserved oligomeric Golgi complex components 5, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356576
  • ENSP00000348983
  • ENSG00000133103
  • ENST00000416691
  • ENSP00000403733
  • ENST00000455146
  • ENSP00000397441

Symbol
  • KIAA1134
  • COD2
  • SHNS
  • CDG2L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
cell type or tissue
0.82
histone modification site profile
0.73
tissue sample
0.66
microRNA
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.77   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.77   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (223)
COG5
Tbio
Novelty:  0.04017657
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG3
Tbio
Novelty:  0.02746711
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG8
Tbio
Novelty:  0.02448169
p_int:  0.999999919
p_ni:  8e-8
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
PKN1
Tchem
Family:  Kinase
Novelty:  0.00780975
p_int:  0.999999876
p_ni:  1.23e-7
p_wrong:  1e-9
Data Source:  BioPlex
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.999999799
p_ni:  2.01e-7
Score:  0.414
Data Source:  BioPlex,STRINGDB
ATP7A
Tbio
Family:  Enzyme
Novelty:  0.00064155
p_int:  0.999999594
p_ni:  4.05e-7
p_wrong:  1e-9
Data Source:  BioPlex
IFT57
Tbio
Novelty:  0.03373199
p_int:  0.99999883
p_ni:  0.00000117
Data Source:  BioPlex
COG7
Tbio
Novelty:  0.07137701
p_int:  0.999998
p_ni:  0.000001998
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG1
Tbio
Novelty:  0.0124285
p_int:  0.999996457
p_ni:  0.000003542
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
KLC2
Tbio
Novelty:  0.06284367
p_int:  0.999995342
p_ni:  0.000004658
Score:  0.159
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
1
3
82
eosinophil percentage of leukocytes
2
1
2
81.1
4
3
2
1.1
70.8
body height
1
1
1
65.9
1
1
0
1.1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
82
eosinophil percentage of leukocytes
2
81.1
2
1.1
70.8
body height
1
65.9
0
1.1
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
component of oligomeric golgi complex 6
VGNC:5049
452550
Macaque
component of oligomeric golgi complex 6
697092
Mouse
MGI:1914792
67542
Rat
RGD:1303283
310411
Dog
component of oligomeric golgi complex 6
VGNC:39452
477296
Species
Name
OMA
EggNOG
Inparanoid
Chimp
component of oligomeric golgi complex 6
Macaque
component of oligomeric golgi complex 6
Mouse
Rat
Dog
component of oligomeric golgi complex 6
Publication Statistics
PubMed Score 35.77
PubMed score by year
PubTator Score 18.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title