Tbio RAX Retinal homeobox protein Rx

Protein Summary

Description

Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter. This gene encodes a homeobox-containing transcription factor that functions in eye development. The gene is expressed early in the eye primordia, and is required for retinal cell fate determination and also regulates stem cell proliferation. Mutations in this gene have been reported in patients with defects in ocular development, including microphthalmia, anophthalmia, and coloboma.[provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q9Y2V3
• Q86V11

Gene Name

• RAX

Ensembl ID

• ENST00000256852
• ENSP00000256852
• ENSG00000134438
• ENST00000334889
• ENSP00000334813

Symbol

• RX
• RX
• MCOP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.76
biological process	0.63
PubMedID	0.62
transcription factor binding site profile	0.61
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.35   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 233   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.35   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0