Tbio KLHDC2 Kelch domain-containing protein 2

Protein Summary

Description

Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.

Uniprot Accession IDs

• Q9Y2U9
• B3KPF9
• Q6IAF0
• Q86TY9

Gene Name

• KLHDC2

Ensembl ID

• ENST00000298307
• ENSP00000298307
• ENSG00000165516
• ENST00000555443
• ENSP00000450944
• ENST00000555739
• ENSP00000450539

Symbol

• HCA33
• LCP
• HCLP1
• HCLP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
transcription factor perturbation	0.98
virus perturbation	0.98
disease perturbation	0.83
transcription factor binding site profile	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.48   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 89   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.48   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0