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Tbio
KLHDC2
Kelch domain-containing protein 2

Protein Summary
Description
Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298307
  • ENSP00000298307
  • ENSG00000165516
  • ENST00000555443
  • ENSP00000450944
  • ENST00000555739
  • ENSP00000450539

Symbol
  • HCA33
  • LCP
  • HCLP1
  • HCLP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.98
virus perturbation
0.98
disease perturbation
0.83
transcription factor binding site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 723.71   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 723.71   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (3)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Protein-Protein Interactions (66)
1 – 10 of 66
SELENOS
Tbio
Novelty: 0.00679742
p_int: 0.999995903
p_ni: 0.000004014
p_wrong: 8.3e-8
Score: 0.495
Data Source: BioPlex,STRINGDB
RNF169
Tbio
Family: Enzyme
Novelty: 0.35418131
p_int: 0.999988877
p_ni: 0.000010554
p_wrong: 5.69e-7
Score: 0.199
Data Source: BioPlex,STRINGDB
CUL5
Tbio
Novelty: 0.01021591
p_int: 0.99998433
p_ni: 0.00001567
Score: 0.308
Data Source: BioPlex,STRINGDB
AFAP1L1
Tbio
Novelty: 0.25835555
p_int: 0.999198293
p_ni: 0.000801111
p_wrong: 5.97e-7
Data Source: BioPlex
FEZ1
Tbio
Novelty: 0.03725421
p_int: 0.997654832
p_ni: 0.002345168
Data Source: BioPlex
FAIM
Tbio
Novelty: 0.03226599
p_int: 0.996913852
p_ni: 0.000002811
p_wrong: 0.003083337
Score: 0.19
Data Source: BioPlex,STRINGDB
NUDCD3
Tbio
Novelty: 0.44149794
p_int: 0.995344935
p_ni: 0.004655065
Data Source: BioPlex
SYDE1
Tbio
Family: Enzyme
Novelty: 0.02387477
p_int: 0.994480156
p_ni: 0.005519843
p_wrong: 1e-9
Data Source: BioPlex
CUL2
Tbio
Novelty: 0.00892549
p_int: 0.994383226
p_ni: 0.005607642
p_wrong: 0.000009133
Score: 0.325
Data Source: BioPlex,STRINGDB
GLMN
Tbio
Novelty: 0.01373749
p_int: 0.992306286
p_ni: 0.007693662
p_wrong: 5.2e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  723.71

PubMed score by year
PubTator Score  32.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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