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Tbio
KLHDC2
Kelch domain-containing protein 2

Protein Summary
Description
Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298307
  • ENSP00000298307
  • ENSG00000165516
  • ENST00000555443
  • ENSP00000450944
  • ENST00000555739
  • ENSP00000450539

Symbol
  • HCA33
  • LCP
  • HCLP1
  • HCLP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.98
virus perturbation
0.98
disease perturbation
0.83
transcription factor binding site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.23   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.23   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (66)
1 – 10 of 66
SELENOS
Tbio
Novelty:  0.01108715
p_int:  0.999995903
p_ni:  0.000004014
p_wrong:  8.3e-8
Score:  0.495
Data Source:  BioPlex,STRINGDB
RNF169
Tbio
Family:  Enzyme
Novelty:  0.28921437
p_int:  0.999988877
p_ni:  0.000010554
p_wrong:  5.69e-7
Score:  0.199
Data Source:  BioPlex,STRINGDB
CUL5
Tbio
Novelty:  0.00792494
p_int:  0.99998433
p_ni:  0.00001567
Score:  0.308
Data Source:  BioPlex,STRINGDB
AFAP1L1
Tbio
Novelty:  0.2636613
p_int:  0.999198293
p_ni:  0.000801111
p_wrong:  5.97e-7
Data Source:  BioPlex
FEZ1
Tbio
Novelty:  0.02695814
p_int:  0.997654832
p_ni:  0.002345168
Data Source:  BioPlex
FAIM
Tbio
Novelty:  0.02606594
p_int:  0.996913852
p_ni:  0.000002811
p_wrong:  0.003083337
Score:  0.19
Data Source:  BioPlex,STRINGDB
NUDCD3
Tbio
Novelty:  0.32026811
p_int:  0.995344935
p_ni:  0.004655065
Data Source:  BioPlex
SYDE1
Tbio
Family:  Enzyme
Novelty:  0.04683299
p_int:  0.994480156
p_ni:  0.005519843
p_wrong:  1e-9
Data Source:  BioPlex
CUL2
Tbio
Novelty:  0.00512916
p_int:  0.994383226
p_ni:  0.005607642
p_wrong:  0.000009133
Score:  0.325
Data Source:  BioPlex,STRINGDB
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.992306286
p_ni:  0.007693662
p_wrong:  5.2e-8
Data Source:  BioPlex
Gene Ontology Terms (3)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
3.8
14.2
age at onset
1
1
0
3.8
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3.8
14.2
age at onset
0
3.8
14.2
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch domain containing 2
VGNC:12549
452890
Macaque
kelch domain containing 2
704580
Mouse
MGI:1916804
69554
Rat
RGD:1306504
299113
Dog
kelch domain containing 2
VGNC:42441
480314
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch domain containing 2
Macaque
kelch domain containing 2
Mouse
Rat
Dog
kelch domain containing 2
Publication Statistics
PubMed Score 66.23
PubMed score by year
PubTator Score 32.50
PubTator score by year