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Tbio
LEMD3
Inner nuclear membrane protein Man1

Protein Summary
Description
Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308330
  • ENSP00000308369
  • ENSG00000174106

Symbol
  • MAN1
  • MAN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.76
interacting protein
0.75
microRNA
0.75
cellular component
0.7
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.08   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.08   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (114)
SMAD2
Tbio
Family:  TF
Novelty:  0.00040166
p_int:  0.999925484
p_ni:  0.000074515
Score:  0.792
Data Source:  BioPlex,STRINGDB
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
p_int:  0.999538185
p_ni:  0.000461815
Score:  0.819
Data Source:  BioPlex,STRINGDB
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.999438936
p_ni:  0.000561063
p_wrong:  1e-9
Data Source:  BioPlex
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
p_int:  0.999418037
p_ni:  0.000581961
p_wrong:  2e-9
Data Source:  BioPlex
SMAD9
Tbio
Family:  TF
Novelty:  0.00285887
p_int:  0.999266515
p_ni:  0.000733485
Score:  0.707
Data Source:  BioPlex,STRINGDB
GP9
Tbio
Novelty:  0.00365769
p_int:  0.998486385
p_ni:  0.001513614
Data Source:  BioPlex
AOC2
Tchem
Family:  Enzyme
Novelty:  0.0048282
p_int:  0.997592199
p_ni:  0.002407801
Score:  0.187
Data Source:  BioPlex,STRINGDB
FAM234B
Tdark
Novelty:  1.53957047
p_int:  0.995912689
p_ni:  0.004087311
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.995038637
p_ni:  0.004961359
p_wrong:  3e-9
Data Source:  BioPlex
MME
Tclin
Family:  Enzyme
Novelty:  0.00019144
p_int:  0.994968151
p_ni:  0.005031849
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Cell Cycle (R-HSA-1640170)

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Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Depolymerisation of the Nuclear Lamina
Reactome
Initiation of Nuclear Envelope Reformation
Reactome
M Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Depolymerisation of the Nuclear Lamina
Initiation of Nuclear Envelope Reformation
M Phase
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hippocampal CA1 volume
2
1
0
14
78.5
granule cell layer dentate gyrus volume
1
1
0
8.8
73.5
hippocampal CA4 volume
1
1
0
7.3
71.5
hippocampal CA3 volume
1
1
0
7.8
70.8
presubiculum volume
1
1
0
5.6
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hippocampal CA1 volume
0
14
78.5
granule cell layer dentate gyrus volume
0
8.8
73.5
hippocampal CA4 volume
0
7.3
71.5
hippocampal CA3 volume
0
7.8
70.8
presubiculum volume
0
5.6
64.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LEM domain containing 3
VGNC:5450
452050
Macaque
LEM domain containing 3
717597
Mouse
MGI:3580376
380664
Rat
RGD:1596822
680066
Dog
LEM domain containing 3
VGNC:42633
608380
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LEM domain containing 3
Macaque
LEM domain containing 3
Mouse
Rat
Dog
LEM domain containing 3
Publication Statistics
PubMed Score 179.08
PubMed score by year
PubTator Score 106.22
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title