Pharos : Target Details

Tchem

Protein Classes

Protein Summary

Description

Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

Gene Name

MAP3K2

Ensembl ID

ENST00000344908
ENSP00000343463
ENSG00000169967
ENST00000409947
ENSP00000387246

Symbol

MAPKKK2
MEKK2
MEKK2
MEKK2B

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1

molecular function	0.99

hub protein	0.92

virus perturbation	0.9

small molecule perturbation	0.81

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.74 (req: < 5)

View Publications

Gene RIFs: 23 (req: <= 3)

View Gene RIFs

Antibodies: 241 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.74 (req: >= 5)

Gene RIFs: 23 (req: > 3)

Antibodies: 241 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2

Explore Approved Drugs

Approved Drugs (2)

1 – 2 of 2

bosutinib

nintedanib

Active Ligands (3)

1 – 3 of 3

CHEMBL388978

CHEMBL603469

CHEMBL2436978

GWAS Traits (1)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
protein C measurement	EFO_0004633	1	1	2		68.8

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
protein C measurement	EFO_0004633	2		68.8

Beta Count

Odds Ratio

Protein Data Bank (4)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (25)

KEGG (3)

PathwayCommons (15)

WikiPathways (7)

Items per page:

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	GnRH signaling pathway	95 targets	path:hsa04912

KEGG	Gap junction	91 targets	path:hsa04540

KEGG	MAPK signaling pathway	295 targets	path:hsa04010

Name	Explore in Pharos	Explore in Source
GnRH signaling pathway	95 targets	path:hsa04912

Gap junction	91 targets	path:hsa04540

MAPK signaling pathway	295 targets	path:hsa04010

Gene Ontology Terms (17)

Functions (6)

Components (3)

Processes (8)

Items per page:

1 – 6 of 6

GO Term	Evidence	Assigned by
protein kinase activity	Inferred from Direct Assay (IDA)	MGI

protein kinase binding	Inferred from Physical Interaction (IPI)	UniProtKB

protein serine/threonine kinase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

MAP kinase kinase kinase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (88)

1 – 10 of 88

See Interactions on String-DB

MAP2K5

Tchem

Family: Kinase

Novelty: 0.00587774

p_int: 0.999999982

p_wrong: 1.8e-8

Score: 0.998

Data Source: BioPlex,STRINGDB

MAP2K4

Tchem

Family: Kinase

Novelty: 0.00252847

Score: 0.962

Data Source: STRINGDB

MAP2K7

Tchem

Family: Kinase

Novelty: 0.00916401

Score: 0.961

Data Source: STRINGDB

SH2D2A

Tbio

Novelty: 0.02356634

Score: 0.951

Data Source: STRINGDB

SMYD3

Tchem

Family: Epigenetic

Novelty: 0.01040802

Score: 0.939

Data Source: STRINGDB

RAP1A

Tchem

Family: Enzyme

Novelty: 0.00375413

Score: 0.937

Data Source: STRINGDB

RAP1B

Tbio

Family: Enzyme

Novelty: 0.00627538

Score: 0.927

Data Source: STRINGDB

SRC

Tclin

Family: Kinase

Novelty: 0.00008479

Score: 0.927

Data Source: STRINGDB

MAP4K3

Tchem

Family: Kinase

Novelty: 0.04596429

Score: 0.909

Data Source: STRINGDB

MAP4K4

Tchem

Family: Kinase

Novelty: 0.00702733

Score: 0.909

Data Source: STRINGDB

Publication Statistics

PubMed Score 76.74

PubMed score by year

PubTator Score 41.06

PubTator score by year

Patents

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Ortholog Sequence Conservation

WebLogo Color Code

PolarG S T Y C

NeutralQ N

BasicK R H

AcidicD E

HydrophobicA V L I P W F M

Compare across kinases on ProKinO

Structural Annotations

Find similar targets by:

UniProt Keyword


3D-structure

ATP-binding

Complete proteome

Cytoplasm

Kinase

Magnesium

Metal-binding

Nucleotide-binding

Nucleus

Phosphoprotein

GWAS Trait


protein C measurement

MGI Phenotype


cardiovascular system phenotype

cellular phenotype

hematopoietic system phenotype

homeostasis/metabolism phenotype

immune system phenotype

reproductive system phenotype