MAP3K2
Mitogen-activated protein kinase kinase kinase 2
Protein Summary
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
- ENST00000344908
- ENSP00000343463
- ENSG00000169967
- ENST00000409947
- ENSP00000387246
- MAPKKK2
- MEKK2
- MEKK2
- MEKK2B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 1 | ||
molecular function | 0.99 | ||
hub protein | 0.92 | ||
virus perturbation | 0.9 | ||
small molecule perturbation | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.41 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 241 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.41 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 241 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (3)
Protein-Protein Interactions (88)
MAP2K5
Family: Kinase
Novelty: 0.00587774
p_int: 0.999999982
p_wrong: 1.8e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (11)
Upstream (2)
Downstream (9)
1 – 2 of 2
Pathways (25)
KEGG (3)
PathwayCommons (15)
WikiPathways (7)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | GnRH signaling pathway | ||||
KEGG | Gap junction | ||||
KEGG | MAPK signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
GnRH signaling pathway | ||||
Gap junction | ||||
MAPK signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (6)
Components (3)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
protein C measurement | 3 | 5 | 6 | 96.7 | |||||
self reported educational attainment | 1 | 1 | 1 | 4 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
protein C measurement | 6 | 96.7 | |||||
self reported educational attainment | 1 | 4 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | mitogen-activated protein kinase kinase kinase 2 | VGNC:14152 | 736244 | |||||
Macaque | mitogen-activated protein kinase kinase kinase 2 | 100424131 | ||||||
Mouse | MGI:1346873 | 26405 | ||||||
Rat | RGD:620967 | 171492 | ||||||
Dog | mitogen-activated protein kinase kinase kinase 2 | VGNC:42972 | 612902 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | mitogen-activated protein kinase kinase kinase 2 | |||||
Macaque | mitogen-activated protein kinase kinase kinase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitogen-activated protein kinase kinase kinase 2 | |||||
Publication Statistics
PubMed Score 83.41
PubMed score by year
PubTator Score 41.06
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (45)
GeneRif Annotations (23)
Items per page:
0 of 0
PMID | Year | Title |
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