MAP3K2
Mitogen-activated protein kinase kinase kinase 2
Protein Classes
Protein Summary
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
- ENST00000344908
- ENSP00000343463
- ENSG00000169967
- ENST00000409947
- ENSP00000387246
- MAPKKK2
- MEKK2
- MEKK2
- MEKK2B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 1 | ||
molecular function | 0.99 | ||
hub protein | 0.92 | ||
virus perturbation | 0.9 | ||
small molecule perturbation | 0.81 | ||
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.74 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 241 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.74 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 241 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
Active Ligands (3)
1 – 3 of 3
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
protein C measurement | 1 | 1 | 2 | 68.8 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
protein C measurement | 2 | 68.8 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | mitogen-activated protein kinase kinase kinase 2 | VGNC:14152 | 736244 | |||||
Macaque | mitogen-activated protein kinase kinase kinase 2 | 100424131 | ||||||
Mouse | MGI:1346873 | 26405 | ||||||
Rat | RGD:620967 | 171492 | ||||||
Dog | mitogen-activated protein kinase kinase kinase 2 | VGNC:42972 | 612902 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | mitogen-activated protein kinase kinase kinase 2 | |||||
Macaque | mitogen-activated protein kinase kinase kinase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitogen-activated protein kinase kinase kinase 2 | |||||
Protein Structure (4 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (25)
KEGG (3)
PathwayCommons (15)
WikiPathways (7)
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | GnRH signaling pathway | ||||
KEGG | Gap junction | ||||
KEGG | MAPK signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
GnRH signaling pathway | ||||
Gap junction | ||||
MAPK signaling pathway | ||||
Gene Ontology Terms (17)
Functions (6)
Components (3)
Processes (8)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (88)
1 – 10 of 88
MAP2K5
Family: Kinase
Novelty: 0.00587774
p_int: 0.999999982
p_wrong: 1.8e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
MAP2K4
Family: Kinase
Novelty: 0.00252847
Score: 0.962
Data Source: STRINGDB
MAP2K7
Family: Kinase
Novelty: 0.00916401
Score: 0.961
Data Source: STRINGDB
SH2D2A
Novelty: 0.02356634
Score: 0.951
Data Source: STRINGDB
SMYD3
Family: Epigenetic
Novelty: 0.01040802
Score: 0.939
Data Source: STRINGDB
RAP1A
Family: Enzyme
Novelty: 0.00375413
Score: 0.937
Data Source: STRINGDB
RAP1B
Family: Enzyme
Novelty: 0.00627538
Score: 0.927
Data Source: STRINGDB
SRC
Family: Kinase
Novelty: 0.00008479
Score: 0.927
Data Source: STRINGDB
MAP4K3
Family: Kinase
Novelty: 0.04596429
Score: 0.909
Data Source: STRINGDB
MAP4K4
Family: Kinase
Novelty: 0.00702733
Score: 0.909
Data Source: STRINGDB
Publication Statistics
PubMed Score 76.74
PubMed score by year
PubTator Score 41.06
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Ortholog Sequence Conservation
PolarG S T Y C
NeutralQ N
BasicK R H
AcidicD E
HydrophobicA V L I P W F M
Find similar targets by:
UniProt Keyword