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Tdark
KCNK7
Potassium channel subfamily K member 7

Protein Summary
Description
Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane. This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340313
  • ENSP00000344820
  • ENSG00000173338
  • ENST00000342202
  • ENSP00000343923
  • ENST00000394216
  • ENSP00000377764
  • ENST00000394217
  • ENSP00000377765

Symbol
  • TWIK3
  • K2p7.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.79
tissue sample
0.7
tissue
0.62
protein domain
0.58
cell line
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.31   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 37   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.31   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 7
VGNC:7506
745474
Mouse
MGI:1341841
16530
Rat
RGD:1565025
499303
Dog
potassium two pore domain channel subfamily K member 7
VGNC:42279
483733
Horse
potassium two pore domain channel subfamily K member 7
VGNC:19301
100051469
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 7
Mouse
Rat
Dog
potassium two pore domain channel subfamily K member 7
Horse
potassium two pore domain channel subfamily K member 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y2U2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Neuronal System
Reactome
Phase 4 - resting membrane potential
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Neuronal System
Phase 4 - resting membrane potential
Potassium Channels
Protein-Protein Interactions (16)
1 – 10 of 16
NUDT6
Tbio
Novelty: 0.03648851
Score: 0.756
Data Source: STRINGDB
EHBP1L1
Tdark
Novelty: 0.39557718
Score: 0.71
Data Source: STRINGDB
TIGD3
Tdark
Novelty: 1.23642174
Score: 0.697
Data Source: STRINGDB
FAM89B
Tbio
Novelty: 0.10306021
Score: 0.683
Data Source: STRINGDB
KCNK18
Tclin
Family: IC
Novelty: 0.01151961
Score: 0.674
Data Source: STRINGDB
FRMD8
Tdark
Novelty: 0.39375892
Score: 0.659
Data Source: STRINGDB
SSSCA1
Tdark
Novelty: 0.53523038
Score: 0.647
Data Source: STRINGDB
CDC42EP2
Tbio
Novelty: 0.21932639
Score: 0.631
Data Source: STRINGDB
MAP3K11
Tchem
Family: Kinase
Novelty: 0.01112378
Score: 0.612
Data Source: STRINGDB
ARRDC3
Tbio
Novelty: 0.04840692
Score: 0.501
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.31

PubMed score by year
PubTator Score  1.24

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer