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Tclin
GPR55
G-protein coupled receptor 55

Protein Summary
Description
May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function. This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392039
  • ENSP00000375893
  • ENSG00000135898
  • ENST00000392040
  • ENSP00000375894
  • ENST00000444078
  • ENSP00000410267
  • ENST00000622008
  • ENSP00000482381

Symbol
  • LPIR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.86
tissue sample
0.71
biological process
0.63
cell type or tissue
0.63
biological term
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.68   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.68   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 41
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (269)
ARRB2
Tbio
Novelty:  0.00148149
p_int:  0.890245833
p_ni:  0.109754166
p_wrong:  1e-9
Score:  0.312
Data Source:  BioPlex,STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.756232991
p_ni:  0.243767009
Score:  0.179
Data Source:  BioPlex,STRINGDB
CNR1
Tclin
Family:  GPCR
Novelty:  0.00060063
Score:  0.989
Data Source:  STRINGDB
CNR2
Tchem
Family:  GPCR
Novelty:  0.00215391
Score:  0.979
Data Source:  STRINGDB
HTR1A
Tclin
Family:  GPCR
Novelty:  0.00015658
Score:  0.947
Data Source:  STRINGDB
GPR18
Tchem
Family:  GPCR
Novelty:  0.0178347
Score:  0.933
Data Source:  STRINGDB
TMIGD3
Tchem
Novelty:  0.00089511
Score:  0.926
Data Source:  STRINGDB
ADORA3
Tchem
Family:  GPCR
Novelty:  0.00089511
Score:  0.926
Data Source:  STRINGDB
ADORA1
Tclin
Family:  GPCR
Novelty:  0.00043697
Score:  0.925
Data Source:  STRINGDB
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
54.4
mean corpuscular volume
1
1
1
46.1
mean reticulocyte volume
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
54.4
mean corpuscular volume
1
46.1
mean reticulocyte volume
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 55
VGNC:10832
470673
Mouse
MGI:2685064
227326
Rat
RGD:1559828
501177
Dog
G protein-coupled receptor 55
VGNC:41438
486157
Horse
G protein-coupled receptor 55 [Source:HGNC Symbol;Acc:HGNC:4511]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 55
Mouse
Rat
Dog
G protein-coupled receptor 55
Horse
G protein-coupled receptor 55 [Source:HGNC Symbol;Acc:HGNC:4511]
Publication Statistics
PubMed Score 296.68
PubMed score by year
PubTator Score 113.16
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title