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Tbio
GDA
Guanine deaminase

Protein Summary
Description
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238018
  • ENSP00000238018
  • ENSG00000119125
  • ENST00000358399
  • ENSP00000351170
  • ENST00000475764
  • ENSP00000436619
  • ENST00000545168
  • ENSP00000437972

Symbol
  • KIAA1258
  • GAH
  • CYPIN
  • GUANASE
  • NEDASIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
small molecule perturbation
0.73
microRNA
0.66
cellular component
0.57
gene perturbation
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.86   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.86   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
1
1
1
38.8
metabolic syndrome
1
1
1
3.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
1
38.8
metabolic syndrome
1
3.1
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanine deaminase
VGNC:4751
472950
Macaque
guanine deaminase
701796
Mouse
MGI:95678
14544
Rat
RGD:621617
83585
Dog
guanine deaminase
VGNC:41154
484169
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanine deaminase
Macaque
guanine deaminase
Mouse
Rat
Dog
guanine deaminase
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y2T3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Purine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Purine catabolism
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (76)
1 – 10 of 76
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.983441665
p_ni:  0.016558312
p_wrong:  2.3e-8
Data Source:  BioPlex
DTX3
Tbio
Family:  Enzyme
Novelty:  0.06212096
p_int:  0.918692367
p_ni:  0.081307633
Score:  0.209
Data Source:  BioPlex,STRINGDB
C7orf31
Tdark
Novelty:  1.72375691
p_int:  0.885050632
p_ni:  0.114949368
Score:  0.379
Data Source:  BioPlex,STRINGDB
MATN3
Tbio
Novelty:  0.00426202
p_int:  0.820741467
p_ni:  0.179258533
Score:  0.379
Data Source:  BioPlex,STRINGDB
HERC3
Tbio
Family:  Enzyme
Novelty:  0.05231675
p_int:  0.764491039
p_ni:  0.235508961
Score:  0.237
Data Source:  BioPlex,STRINGDB
APRT
Tchem
Family:  Enzyme
Novelty:  0.00483077
Score:  0.984
Data Source:  STRINGDB
PNP
Tclin
Family:  Enzyme
Novelty:  0.0019084
Score:  0.984
Data Source:  STRINGDB
XDH
Tclin
Family:  Enzyme
Novelty:  0.00054185
Score:  0.959
Data Source:  STRINGDB
HPRT1
Tchem
Family:  Enzyme
Novelty:  0.00032232
Score:  0.953
Data Source:  STRINGDB
ATRIP
Tbio
Novelty:  0.01415267
Score:  0.885
Data Source:  STRINGDB
Publication Statistics
PubMed Score  62.86

PubMed score by year
PubTator Score  732.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer