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Tbio
AP3M1
AP-3 complex subunit mu-1

Protein Summary
Description
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the budding of vesicles from the Golgi membrane, and it may directly function in protein sorting to the endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355264
  • ENSP00000347408
  • ENSG00000185009
  • ENST00000372745
  • ENSP00000361831
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
microRNA
0.85
protein domain
0.85
virus perturbation
0.85
interacting protein
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.4   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.4   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cardiac troponin I measurement
1
1
1
42.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cardiac troponin I measurement
1
42.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 3 subunit mu 1
VGNC:7219
450532
Macaque
adaptor related protein complex 3 mu 1 subunit
705729
Mouse
MGI:1929212
55946
Rat
RGD:620417
171126
Dog
adaptor related protein complex 3 subunit mu 1
VGNC:37966
489052
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 3 subunit mu 1
Macaque
adaptor related protein complex 3 mu 1 subunit
Mouse
Rat
Dog
adaptor related protein complex 3 subunit mu 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y2T2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Metabolism of proteins
Reactome
Protein folding
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Metabolism of proteins
Protein folding
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Protein-Protein Interactions (100)
1 – 10 of 100
AP3S1
Tbio
Novelty: 0.12425009
p_int: 1
Score: 0.989
Data Source: BioPlex,STRINGDB
AP3B2
Tbio
Novelty: 0.11897342
p_int: 0.999999992
p_ni: 3e-9
p_wrong: 5e-9
Score: 0.987
Data Source: BioPlex,STRINGDB
AP3M2
Tbio
Novelty: 0.18164255
p_int: 0.999999954
p_ni: 4.6e-8
Score: 0.964
Data Source: BioPlex,STRINGDB
FERMT2
Tbio
Novelty: 0.01020276
p_int: 0.99999992
p_ni: 7.9e-8
p_wrong: 1e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
AP3S2
Tdark
Novelty: 0.25186243
p_int: 0.999999878
p_ni: 1.16e-7
p_wrong: 6e-9
Score: 0.98
Data Source: BioPlex,STRINGDB
AP3B1
Tbio
Novelty: 0.03117931
p_int: 0.999999797
p_ni: 2.03e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
RABL6
Tbio
Family: Enzyme
Novelty: 0.11501478
p_int: 0.999999259
p_ni: 7.4e-7
Score: 0.328
Data Source: BioPlex,STRINGDB
EPB41L3
Tbio
Novelty: 0.00915217
p_int: 0.999998815
p_ni: 0.000001185
Data Source: BioPlex
AP3D1
Tbio
Novelty: 0.04425592
p_int: 0.999997498
p_ni: 0.000002502
Score: 0.999
Data Source: BioPlex,STRINGDB
CAMKV
Tbio
Family: Kinase
Novelty: 0.17794181
p_int: 0.999820078
p_ni: 0.000179922
Data Source: BioPlex
Publication Statistics
PubMed Score  1.40

PubMed score by year
PubTator Score  0.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer