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Tchem
AXIN2
Axin-2

Protein Summary
Description
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity). The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307078
  • ENSP00000302625
  • ENSG00000168646

Symbol
  • AXIL
  • ODCRCS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
transcription factor perturbation
0.96
PubMedID
0.85
transcription factor binding site profile
0.82
cellular component
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.21   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.21   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
5
95.9
body height
1
1
1
25.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
95.9
body height
1
25.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
axin 2
VGNC:9129
468301
Mouse
MGI:1270862
12006
Rat
RGD:69259
29134
Dog
axin 2
VGNC:38325
490903
Horse
axin 2
VGNC:15717
100630049
Species
Name
OMA
EggNOG
Inparanoid
Chimp
axin 2
Mouse
Rat
Dog
axin 2
Horse
axin 2
Pathways (52)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Binding of TCF/LEF:CTNNB1 to target gene promoters
Reactome
Ca2+ pathway
Reactome
Degradation of AXIN
Reactome
Degradation of beta-catenin by the destruction complex
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Binding of TCF/LEF:CTNNB1 to target gene promoters
Ca2+ pathway
Degradation of AXIN
Degradation of beta-catenin by the destruction complex
Gene Ontology Terms (31)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (240)
1 – 10 of 240
GSK3A
Tclin
Family: Kinase
Novelty: 0.00925708
p_int: 0.999997385
p_ni: 0.000002614
p_wrong: 1e-9
Score: 0.989
Data Source: BioPlex,STRINGDB
GSK3B
Tclin
Family: Kinase
Novelty: 0.00095115
p_int: 0.969328724
p_ni: 0.030454775
p_wrong: 0.000216501
Score: 0.995
Data Source: BioPlex,STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.996
Data Source: STRINGDB
APC
Tbio
Novelty: 0.00168376
Score: 0.994
Data Source: STRINGDB
TNKS
Tchem
Family: Enzyme
Novelty: 0.00404545
Score: 0.99
Data Source: Reactome,STRINGDB
LEF1
Tchem
Family: TF
Novelty: 0.00168638
Score: 0.988
Data Source: STRINGDB
TCF7L2
Tbio
Family: TF
Novelty: 0.00178694
Score: 0.987
Data Source: STRINGDB
APC2
Tbio
Novelty: 0.02034048
Score: 0.982
Data Source: STRINGDB
TNKS2
Tchem
Family: Enzyme
Novelty: 0.00938509
Score: 0.976
Data Source: Reactome,STRINGDB
DVL1
Tchem
Novelty: 0.00356876
Score: 0.975
Data Source: STRINGDB
Publication Statistics
PubMed Score  301.21

PubMed score by year
PubTator Score  190.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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