You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CRYL1
Lambda-crystallin homolog

Protein Summary
Description
The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene in the rabbit is thought to serve a structural role in the lens of the eye. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298248
  • ENSP00000298248
  • ENSG00000165475
  • ENST00000382812
  • ENSP00000372262
  • ENST00000643750
  • ENSP00000493818

Symbol
  • CRY
  • GDH
  • HEL30
  • gul3DH
  • lambda-CRY
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.89
transcription factor perturbation
0.84
virus perturbation
0.83
cellular component
0.79


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.54   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.54   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
crystallin lambda 1
VGNC:13075
452458
Macaque
crystallin lambda 1
703988
Mouse
MGI:1915881
68631
Rat
RGD:631427
290277
Dog
crystallin lambda 1
VGNC:39647
486050
Species
Name
OMA
EggNOG
Inparanoid
Chimp
crystallin lambda 1
Macaque
crystallin lambda 1
Mouse
Rat
Dog
crystallin lambda 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y2S2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Formation of xylulose-5-phosphate (R-HSA-5661270)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of xylulose-5-phosphate
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Formation of xylulose-5-phosphate
Metabolism
Metabolism of carbohydrates
Protein-Protein Interactions (101)
1 – 10 of 101
F2R
Tclin
Family:  GPCR
Novelty:  0.00080964
p_int:  0.999513499
p_ni:  0.000472542
p_wrong:  0.000013959
Data Source:  BioPlex
PKD2
Tchem
Family:  IC
Novelty:  0.00305329
p_int:  0.998234404
p_ni:  0.001765596
Data Source:  BioPlex
TRIM65
Tbio
Novelty:  0.09830696
p_int:  0.996970524
p_ni:  0.003029435
p_wrong:  4.1e-8
Data Source:  BioPlex
HTT
Tchem
Novelty:  0.00034051
p_int:  0.99578395
p_ni:  0.00421605
Data Source:  BioPlex
SPG11
Tbio
Novelty:  0.00697875
p_int:  0.995257475
p_ni:  0.004742241
p_wrong:  2.84e-7
Score:  0.169
Data Source:  BioPlex,STRINGDB
ANAPC5
Tbio
Family:  Enzyme
Novelty:  0.02102572
p_int:  0.994506982
p_ni:  0.005493018
Data Source:  BioPlex
C5orf34
Tdark
Novelty:  1.01063928
p_int:  0.984008009
p_ni:  0.015991985
p_wrong:  6e-9
Data Source:  BioPlex
DYNC2H1
Tbio
Novelty:  0.01306616
p_int:  0.97397711
p_ni:  0.02602289
Score:  0.167
Data Source:  BioPlex,STRINGDB
SMG7
Tbio
Novelty:  0.03394393
p_int:  0.966081907
p_ni:  0.033910348
p_wrong:  0.000007745
Data Source:  BioPlex
HAUS5
Tbio
Novelty:  0.99720546
p_int:  0.963035106
p_ni:  0.036964894
Data Source:  BioPlex
Publication Statistics
PubMed Score  21.54

PubMed score by year
PubTator Score  11.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer