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Tbio
MRPS7
28S ribosomal protein S7, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. In the prokaryotic ribosome, the comparable protein is thought to play an essential role in organizing the 3' domain of the 16 S rRNA in the vicinity of the P- and A-sites. Pseudogenes corresponding to this gene are found on chromosomes 8p and 12p. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245539
  • ENSP00000245539
  • ENSG00000125445

Symbol
  • S7mt
  • MRP-S
  • RP-S7
  • RPMS7
  • MRP-S7
  • COXPD34
  • bMRP27a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.96
histone modification site profile
0.93
interacting protein
0.87
tissue sample
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 565.78   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 565.78   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S7
VGNC:9447
468329
Macaque
mitochondrial ribosomal protein S7
701800
Mouse
MGI:1354367
50529
Rat
RGD:1309164
113958
Dog
mitochondrial ribosomal protein S7
VGNC:43426
609623
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S7
Macaque
mitochondrial ribosomal protein S7
Mouse
Rat
Dog
mitochondrial ribosomal protein S7
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y2R9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (542)
1 – 10 of 542
USP28
Tbio
Family: Enzyme
Novelty: 0.02432294
p_int: 0.999999997
p_ni: 3e-9
p_wrong: 1e-9
Data Source: BioPlex
FEZ2
Tbio
Novelty: 0.1716508
p_int: 0.999998187
p_ni: 0.000001813
Data Source: BioPlex
GUF1
Tbio
Novelty: 0.00422028
p_int: 0.999915877
p_ni: 0.000084119
p_wrong: 4e-9
Score: 0.869
Data Source: BioPlex,STRINGDB
MRPS18C
Tdark
Novelty: 0.42868428
p_int: 0.997920004
p_ni: 0.002079996
Score: 0.993
Data Source: BioPlex,STRINGDB
MRPS18B
Tbio
Novelty: 0.14519418
p_int: 0.997705857
p_ni: 0.002294143
Score: 0.996
Data Source: BioPlex,STRINGDB
MRPS17
Tdark
Novelty: 0.46103276
p_int: 0.99636428
p_ni: 0.00363572
Score: 0.992
Data Source: BioPlex,STRINGDB
MRPS27
Tbio
Novelty: 0.22058227
p_int: 0.995946685
p_ni: 0.004053315
Score: 0.98
Data Source: BioPlex,STRINGDB
MRPS34
Tbio
Novelty: 0.29355603
p_int: 0.995066861
p_ni: 0.004933139
Score: 0.987
Data Source: BioPlex,STRINGDB
MRPS25
Tdark
Novelty: 0.59354314
p_int: 0.993693783
p_ni: 0.006306217
Score: 0.998
Data Source: BioPlex,STRINGDB
MRPS15
Tdark
Novelty: 0.37070563
p_int: 0.992754824
p_ni: 0.007245176
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  565.78

PubMed score by year
PubTator Score  7.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer