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Tdark
MRPS17
28S ribosomal protein S17, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S17P family. The encoded protein is moderately conserved between human mitochondrial and prokaryotic ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 1p, 3p, 6q, 14p, 18q, and Xq. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285298
  • ENSP00000285298
  • ENSG00000239789

Symbol
  • RPMS17
  • S17mt
  • RPMS17
  • HSPC011
  • MRP-S17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
interacting protein
0.79
virus perturbation
0.72
gene perturbation
0.71
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.28   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.28   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (143)
1 – 10 of 143
NOA1
Tbio
Novelty:  0.01478325
p_int:  0.999991556
p_ni:  0.000008444
Data Source:  BioPlex
MRPS33
Tdark
Novelty:  0.27300643
p_int:  0.999717217
p_ni:  0.000282783
Score:  0.992
Data Source:  BioPlex,STRINGDB
DNAJC21
Tdark
Novelty:  0.05368949
p_int:  0.998859218
p_ni:  2.4e-8
p_wrong:  0.001140758
Data Source:  BioPlex
STRBP
Tbio
Novelty:  0.00919158
p_int:  0.998755944
p_ni:  0.001244056
Data Source:  BioPlex
DDX55
Tdark
Family:  Enzyme
Novelty:  0.27887497
p_int:  0.998664501
p_ni:  0.001335286
p_wrong:  2.13e-7
Data Source:  BioPlex
MRPS11
Tdark
Novelty:  0.29449255
p_int:  0.998326457
p_ni:  0.001673543
Score:  0.987
Data Source:  BioPlex,STRINGDB
MRPS28
Tdark
Novelty:  0.58823529
p_int:  0.998301375
p_ni:  0.001698625
Score:  0.987
Data Source:  BioPlex,STRINGDB
DAP3
Tbio
Novelty:  0.05551866
p_int:  0.998132185
p_ni:  0.001867815
Score:  0.962
Data Source:  BioPlex,STRINGDB
LSM11
Tbio
Novelty:  0.10694492
p_int:  0.998117018
p_ni:  0.001806925
p_wrong:  0.000076057
Data Source:  BioPlex
MRPS9
Tdark
Novelty:  0.22906484
p_int:  0.997877267
p_ni:  0.002122733
Score:  0.953
Data Source:  BioPlex,STRINGDB
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
3
7
13
93.3
glycine measurement
3
2
3
90.8
lymphocyte count
2
2
2
86.1
blood metabolite measurement
2
1
2
69.8
body height
1
1
1
67.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
13
93.3
glycine measurement
3
90.8
lymphocyte count
2
86.1
blood metabolite measurement
2
69.8
body height
1
67.3
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 713 [Source:HGNC Symbol;Acc:HGNC:22043]
Mouse
MGI:1913508
66258
Rat
RGD:1307650
288621
Dog
mitochondrial ribosomal protein S17
100688077
Chicken
mitochondrial ribosomal protein S17
CGNC:1698
417538
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 713 [Source:HGNC Symbol;Acc:HGNC:22043]
Mouse
Rat
Dog
mitochondrial ribosomal protein S17
Chicken
mitochondrial ribosomal protein S17
Publication Statistics
PubMed Score 2.28
PubMed score by year
PubTator Score 0.14
PubTator score by year