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Tchem
PTPN22
Tyrosine-protein phosphatase non-receptor type 22

Protein Summary
Description
Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associate ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000460620
  • ENSP00000433141
  • ENSG00000134242

Symbol
  • PTPN8
  • LYP
  • PEP
  • LYP1
  • LYP2
  • PTPN8
  • PTPN22.5
  • PTPN22.6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.88
phenotype
0.88
gene perturbation
0.84
trait
0.75
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 709.25   (req: < 5)
Gene RIFs: 386   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 709.25   (req: >= 5)
Gene RIFs: 386   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 34
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
10
2
1
1.7
99.4
2
2
0
1.5
96.1
4
1
0
2
95.8
2
1
0
1.8
92.8
6
1
0
1.4
92.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.7
99.4
0
1.5
96.1
0
2
95.8
0
1.8
92.8
0
1.4
92.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, non-receptor type 22
VGNC:9886
457136
Macaque
protein tyrosine phosphatase, non-receptor type 22
707433
Mouse
MGI:107170
19260
Rat
RGD:1307992
295338
Dog
protein tyrosine phosphatase, non-receptor type 22
VGNC:45175
483124
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, non-receptor type 22
Macaque
protein tyrosine phosphatase, non-receptor type 22
Mouse
Rat
Dog
protein tyrosine phosphatase, non-receptor type 22
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y2R2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Phosphorylation of CD3 and TCR zeta chains
Reactome
TCR signaling
Reactome
Translocation of ZAP-70 to Immunological synapse
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Phosphorylation of CD3 and TCR zeta chains
TCR signaling
Translocation of ZAP-70 to Immunological synapse
Gene Ontology Terms (39)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (281)
1 – 10 of 281
PRKAR2B
Tbio
Family: Enzyme
Novelty: 0.00456972
p_int: 0.97835194
p_ni: 0.021642643
p_wrong: 0.000005417
Data Source: BioPlex
CSK
Tchem
Family: Kinase
Novelty: 0.00186612
Score: 0.994
Data Source: Reactome,STRINGDB
ZAP70
Tchem
Family: Kinase
Novelty: 0.0011564
Score: 0.987
Data Source: Reactome,STRINGDB
LCK
Tclin
Family: Kinase
Novelty: 0.00058377
Score: 0.987
Data Source: Reactome,STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.98
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.98
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.98
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.98
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.98
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.98
Data Source: STRINGDB
Publication Statistics
PubMed Score  709.25

PubMed score by year
PubTator Score  1361.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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