Tchem PTPN22 Tyrosine-protein phosphatase non-receptor type 22

Protein Summary

Description

Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q9Y2R2
• A0N0K6
• B1ALC8
• D4NZ71
• E9PLD8
• E9PPI1
• O95063
• O95064
• Q6IPX8
• Q8WVM1

Gene Name

• PTPN22

Ensembl ID

• ENST00000460620
• ENSP00000433141
• ENSG00000134242

Symbol

• PTPN8
• LYP
• PEP
• LYP1
• LYP2
• PTPN8
• PTPN22.5
• PTPN22.6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease	0.88
phenotype	0.88
gene perturbation	0.84
trait	0.75
protein domain	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 760.97   (req: < 5)

Gene RIFs: 449   (req: <= 3)

Antibodies: 276   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 760.97   (req: >= 5)

Gene RIFs: 449   (req: > 3)

Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 39

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0