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Tbio
LAMTOR2
Ragulator complex protein LAMTOR2

Protein Summary
Description
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368302
  • ENSP00000357285
  • ENSG00000116586
  • ENST00000368304
  • ENSP00000357287
  • ENST00000368305
  • ENSP00000357288

Symbol
  • MAPBPIP
  • ROBLD3
  • p14
  • ENDAP
  • ROBLD3
  • HSPC003
  • MAPBPIP
  • MAPKSP1AP
  • Ragulator2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
transcription factor binding site profile
0.86
cellular component
0.83
histone modification site profile
0.81
disease perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.62   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.62   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
1
1.5
24.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.5
24.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
VGNC:8350
107973412
Macaque
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
718110
Mouse
MGI:1932697
83409
Rat
RGD:1562501
295234
Horse
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
VGNC:19575
100063939
Species
Name
OMA
EggNOG
Inparanoid
Chimp
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
Macaque
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
Mouse
Rat
Horse
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y2Q5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (28)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Cytokine Signaling in Immune system
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
Reactome
FLT3 Signaling
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Cytokine Signaling in Immune system
Energy dependent regulation of mTOR by LKB1-AMPK
FLT3 Signaling
Protein-Protein Interactions (212)
1 – 10 of 212
LAMTOR5
Tbio
Novelty: 0.003692
p_int: 0.999976012
p_ni: 0.000023988
Score: 0.999
Data Source: BioPlex,STRINGDB
BORCS6
Tdark
Novelty: 0.83789033
p_int: 0.999926155
p_ni: 0.000073839
p_wrong: 6e-9
Score: 0.465
Data Source: BioPlex,STRINGDB
LAMTOR4
Tdark
Novelty: 0.24218646
p_int: 0.99559312
p_ni: 0.00440688
Score: 0.999
Data Source: BioPlex,STRINGDB
LAMTOR3
Tbio
Novelty: 0.050644
p_int: 0.993364653
p_ni: 0.006635347
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
LAMTOR1
Tbio
Novelty: 0.04952213
p_int: 0.991684749
p_ni: 0.008315251
Score: 0.999
Data Source: BioPlex,STRINGDB
MTOR
Tclin
Family: Kinase
Novelty: 0.00012333
Score: 0.999
Data Source: STRINGDB
RRAGC
Tbio
Novelty: 0.01462756
Score: 0.999
Data Source: STRINGDB
RRAGA
Tbio
Novelty: 0.02022668
Score: 0.999
Data Source: STRINGDB
RPTOR
Tbio
Novelty: 0.00119147
Score: 0.999
Data Source: STRINGDB
SLC38A9
Tbio
Family: Transporter
Novelty: 0.0879703
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.62

PubMed score by year
PubTator Score  5.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer