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Tchem
GSTK1
Glutathione S-transferase kappa 1

Protein Summary
Description
Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB). This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358406
  • ENSP00000351181
  • ENSG00000197448
  • ENST00000409500
  • ENSP00000386944
  • ENST00000443571
  • ENSP00000415813
  • ENST00000479303
  • ENSP00000431049

Symbol
  • GST
  • GST13
  • hGSTK1
  • GSTK1-1
  • GST13-13
  • GST 13-13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.99
disease perturbation
0.93
interacting protein
0.92
gene perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.5   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 338   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.5   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
1 – 1 of 1
glutathione
Rendered image for glutathione
Protein-Protein Interactions (89)
1 – 10 of 89
TK2
Tchem
Family:  Kinase
Novelty:  0.10642442
p_int:  0.999999719
p_ni:  2.79e-7
p_wrong:  2e-9
Score:  0.275
Data Source:  BioPlex,STRINGDB
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.998975422
p_ni:  0.001024578
Data Source:  BioPlex
LIMA1
Tbio
Novelty:  0.02718476
p_int:  0.993309424
p_ni:  0.006690576
Score:  0.228
Data Source:  BioPlex,STRINGDB
LDHD
Tbio
Family:  Enzyme
Novelty:  0.0230704
p_int:  0.992662901
p_ni:  0.007336844
p_wrong:  2.55e-7
Data Source:  BioPlex
PAG1
Tbio
Novelty:  0.01390911
p_int:  0.901674045
p_ni:  0.098325349
p_wrong:  6.07e-7
Score:  0.177
Data Source:  BioPlex,STRINGDB
DCAF8
Tbio
Novelty:  0.12456534
p_int:  0.843210201
p_ni:  0.156789794
p_wrong:  5e-9
Data Source:  BioPlex
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.834030467
p_ni:  0.165969533
Data Source:  BioPlex
CST8
Tbio
Novelty:  0.02316886
p_int:  0.78365036
p_ni:  0.216346704
p_wrong:  0.000002936
Data Source:  BioPlex
EPHX2
Tchem
Family:  Enzyme
Novelty:  0.00430741
Score:  0.947
Data Source:  STRINGDB
CAT
Tbio
Family:  Enzyme
Novelty:  0.00181888
Score:  0.937
Data Source:  STRINGDB
Pathways (15)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Metabolism
Reactome
Peroxisomal protein import
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glutathione conjugation
Metabolism
Peroxisomal protein import
Phase II - Conjugation of compounds
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutathione S-transferase kappa 1
VGNC:4382
463802
Macaque
glutathione S-transferase kappa 1
704240
Mouse
MGI:1923513
76263
Rat
RGD:735188
297029
Dog
glutathione S-transferase kappa 1
475518
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutathione S-transferase kappa 1
Macaque
glutathione S-transferase kappa 1
Mouse
Rat
Dog
glutathione S-transferase kappa 1
Publication Statistics
PubMed Score 25.50
PubMed score by year
PubTator Score 3414.57
PubTator score by year