GSTK1
Glutathione S-transferase kappa 1
Protein Summary
Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB). This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
- ENST00000358406
- ENSP00000351181
- ENSG00000197448
- ENST00000409500
- ENSP00000386944
- ENST00000443571
- ENSP00000415813
- ENST00000479303
- ENSP00000431049
- GST
- GST13
- hGSTK1
- GSTK1-1
- GST13-13
- GST 13-13
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.99 | ||
transcription factor perturbation | 0.99 | ||
disease perturbation | 0.93 | ||
interacting protein | 0.92 | ||
gene perturbation | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.38 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 338 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.38 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 338 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1