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Tbio
ATP8A1
Phospholipid-transporting ATPase IA

Protein Summary
Description
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells. The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identif ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264449
  • ENSP00000264449
  • ENSG00000124406
  • ENST00000381668
  • ENSP00000371084

Symbol
  • ATPIA
  • ATPIA
  • ATPP2
  • ATPASEII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
metabolite
0.98
transcription factor perturbation
0.98
protein domain
0.92
cellular component
0.81


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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.63   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.63   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
snoring measurement
1
1
0
1
48.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
snoring measurement
0
1
48.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase phospholipid transporting 8A1
VGNC:7577
461189
Macaque
ATPase phospholipid transporting 8A1
702630
Mouse
MGI:1330848
11980
Rat
RGD:1309619
289615
Dog
ATPase phospholipid transporting 8A1
VGNC:38287
607976
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase phospholipid transporting 8A1
Macaque
ATPase phospholipid transporting 8A1
Mouse
Rat
Dog
ATPase phospholipid transporting 8A1
Pathways (48)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Ion channel transport
Reactome
Ion transport by P-type ATPases
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Ion channel transport
Ion transport by P-type ATPases
Neutrophil degranulation
Protein-Protein Interactions (172)
1 – 10 of 172
SLC6A20
Tbio
Family: Transporter
Novelty: 0.01435823
p_int: 0.999999992
p_ni: 8e-9
Data Source: BioPlex
SLC17A2
Tdark
Family: Transporter
Novelty: 0.23941275
p_int: 0.994555087
p_ni: 2.21e-7
p_wrong: 0.005444692
Score: 0.245
Data Source: BioPlex,STRINGDB
TMEM30A
Tbio
Novelty: 0.05115559
Score: 0.986
Data Source: STRINGDB
ANO6
Tbio
Family: IC
Novelty: 0.01288434
Score: 0.929
Data Source: STRINGDB
P2RX1
Tchem
Family: IC
Novelty: 0.00286826
Score: 0.924
Data Source: STRINGDB
SCAMP1
Tbio
Novelty: 0.03293648
Score: 0.919
Data Source: STRINGDB
DDOST
Tchem
Family: Enzyme
Novelty: 0.01797594
Score: 0.915
Data Source: STRINGDB
LAMP1
Tbio
Novelty: 0.00067563
Score: 0.913
Data Source: STRINGDB
STOM
Tbio
Novelty: 0.00459891
Score: 0.912
Data Source: STRINGDB
ORMDL3
Tbio
Novelty: 0.00958976
Score: 0.911
Data Source: STRINGDB
Publication Statistics
PubMed Score  51.63

PubMed score by year
PubTator Score  51.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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