Tbio ATP8A1 Phospholipid-transporting ATPase IA

Protein Summary

Description

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells. The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI). The protein encoded by this gene is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y2Q0
• Q32M35
• Q32M36
• Q4W5J7
• Q4W5P2

Gene Name

• ATP8A1

Ensembl ID

• ENST00000264449
• ENSP00000264449
• ENSG00000124406
• ENST00000381668
• ENSP00000371084

Symbol

• ATPIA
• ATPIA
• ATPP2
• ATPASEII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
metabolite	0.98
transcription factor perturbation	0.98
protein domain	0.92
cellular component	0.81

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Phospholipid-transporting Atpase Ia

Protein / Hydrolase / Phospholipid-transporting Atpase Ia

DTO Classes

Protein / Transporter / P-type Atpases / Phospholipid-transporting Atpases / Phospholipid-transporting Atpase Ia

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.27   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 73   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.27   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0