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Tbio
RCL1
RNA 3'-terminal phosphate cyclase-like protein

Protein Summary
Description
Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381728
  • ENSP00000371147
  • ENSG00000120158
  • ENST00000381730
  • ENSP00000371149
  • ENST00000381750
  • ENSP00000371169
  • ENST00000448872
  • ENSP00000388096

Symbol
  • RNAC
  • RPC2
  • RPCL1
  • RTC2
  • RNAC
  • RPCL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
protein domain
0.85
disease perturbation
0.83
virus perturbation
0.83
transcription factor binding site profile
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.7   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.7   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
6
4
6
95.7
platelet count
5
9
9
5.6
95.3
mean corpuscular hemoglobin
4
4
4
94.7
mean corpuscular hemoglobin concentration
2
2
2
93.5
red blood cell density measurement
2
2
2
93.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
6
95.7
platelet count
9
5.6
95.3
mean corpuscular hemoglobin
4
94.7
mean corpuscular hemoglobin concentration
2
93.5
red blood cell density measurement
2
93.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA terminal phosphate cyclase like 1
VGNC:9196
464978
Mouse
MGI:1913275
59028
Dog
RNA terminal phosphate cyclase like 1
VGNC:45444
484183
Horse
RNA terminal phosphate cyclase like 1
VGNC:22271
100059280
Cow
RNA terminal phosphate cyclase like 1
VGNC:33830
768075
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA terminal phosphate cyclase like 1
Mouse
Dog
RNA terminal phosphate cyclase like 1
Horse
RNA terminal phosphate cyclase like 1
Cow
RNA terminal phosphate cyclase like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y2P8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (252)
1 – 10 of 252
KLHL21
Tbio
Novelty: 0.20694121
p_int: 0.999994962
p_ni: 0.000005037
p_wrong: 1e-9
Data Source: BioPlex
BMS1
Tbio
Novelty: 0.0349992
p_int: 0.999941226
p_ni: 0.000058774
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
LETM1
Tbio
Novelty: 0.01542461
p_int: 0.997877174
p_ni: 0.002122826
Data Source: BioPlex
EMB
Tbio
Novelty: 0.00135577
p_int: 0.996172835
p_ni: 0.000876021
p_wrong: 0.002951144
Data Source: BioPlex
ARHGEF12
Tbio
Novelty: 0.01365866
p_int: 0.99368085
p_ni: 0.006319137
p_wrong: 1.3e-8
Data Source: BioPlex
HERC1
Tbio
Family: Enzyme
Novelty: 0.04318441
p_int: 0.981048062
p_ni: 0.018951938
Data Source: BioPlex
APBB1
Tbio
Novelty: 0.00630564
p_int: 0.917262572
p_ni: 0.08273742
p_wrong: 8e-9
Data Source: BioPlex
TUBA4A
Tchem
Novelty: 0.00820546
p_int: 0.801164098
p_ni: 0.198835902
Data Source: BioPlex
ARL5B
Tbio
Family: Enzyme
Novelty: 0.03703395
p_int: 0.798703735
p_ni: 0.201282966
p_wrong: 0.000013299
Data Source: BioPlex
IMP4
Tdark
Novelty: 9.64444444
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  45.70

PubMed score by year
PubTator Score  7.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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