You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLC27A5
Bile acyl-CoA synthetase

Protein Summary
Description
Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263093
  • ENSP00000263093
  • ENSG00000083807
  • ENST00000601355
  • ENSP00000470368

Symbol
  • ACSB
  • ACSVL6
  • FACVL3
  • FATP5
  • BAL
  • ACSB
  • BACS
  • FATP5
  • ACSVL6
  • FACVL3
  • FATP-5
  • VLACSR
  • VLCSH2
  • VLCS-H2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
cellular component
0.73
kinase perturbation
0.66
cell type or tissue
0.63
protein domain
0.58


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.68   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.68   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
1
1
45
mean reticulocyte volume
1
1
1
22.3
heel bone mineral density
1
1
1
20.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
45
mean reticulocyte volume
1
22.3
heel bone mineral density
1
20.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 27 member 5
VGNC:7783
456351
Macaque
solute carrier family 27 member 5
713713
Mouse
MGI:1347100
26459
Rat
RGD:708535
79111
Horse
solute carrier family 27 member 5
VGNC:23133
100051678
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 27 member 5
Macaque
solute carrier family 27 member 5
Mouse
Rat
Horse
solute carrier family 27 member 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y2P5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (38)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Recycling of bile acids and salts
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Metabolism
Metabolism of lipids
Metabolism of steroids
Recycling of bile acids and salts
Gene Ontology Terms (19)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (56)
1 – 10 of 56
BAAT
Tbio
Family: Enzyme
Novelty: 0.01336714
Score: 0.965
Data Source: STRINGDB
SCP2
Tchem
Novelty: 0.00183736
Score: 0.952
Data Source: STRINGDB
CYP27A1
Tchem
Family: Enzyme
Novelty: 0.00071796
Score: 0.939
Data Source: STRINGDB
AMACR
Tbio
Family: Enzyme
Novelty: 0.00218306
Score: 0.932
Data Source: STRINGDB
ACOT8
Tbio
Family: Enzyme
Novelty: 0.02218214
Score: 0.809
Data Source: STRINGDB
COASY
Tbio
Family: Enzyme
Novelty: 0.00294867
Score: 0.71
Data Source: STRINGDB
ACSBG2
Tbio
Family: Enzyme
Novelty: 0.1072938
Score: 0.695
Data Source: STRINGDB
ACSL1
Tbio
Family: Enzyme
Novelty: 0.00336161
Score: 0.689
Data Source: STRINGDB
ZNF132
Tbio
Family: TF
Novelty: 0.29109733
Score: 0.655
Data Source: STRINGDB
ZNF584
Tdark
Family: TF
Novelty: 1.73351478
Score: 0.618
Data Source: STRINGDB
Publication Statistics
PubMed Score  60.68

PubMed score by year
PubTator Score  215.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: