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Tbio
HIF3A
Hypoxia-inducible factor 3-alpha

Protein Summary
Description
Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:11573933, PubMed:16126907, PubMed:19694616, PubMed:20416395, PubMed:21069422). Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity). Isoform 2: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Also inhibits hypoxia-inducible ARNT-mediated gene expression. Isoform 3: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. isoform 4: Attenuates the ability of transcript ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244303
  • ENSP00000244303
  • ENSG00000124440
  • ENST00000300862
  • ENSP00000300862
  • ENST00000377670
  • ENSP00000366898

Symbol
  • BHLHE17
  • MOP7
  • PASD7
  • IPAS
  • MOP7
  • PASD7
  • HIF-3A
  • bHLHe17
  • HIF3-alpha-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
protein domain
0.73
transcription factor
0.7
transcription factor perturbation
0.68
microRNA
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.18   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 332   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.18   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 332   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
33.4
lymphocyte count
2
1
2
16.4
2
1
0
1.1
16.3
eosinophil percentage of leukocytes
1
1
1
4.5
1
1
0
1.1
3.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
33.4
lymphocyte count
2
16.4
0
1.1
16.3
eosinophil percentage of leukocytes
1
4.5
0
1.1
3.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hypoxia inducible factor 3 subunit alpha
VGNC:7686
456149
Macaque
hypoxia inducible factor 3 alpha subunit
717188
Mouse
MGI:1859778
53417
Rat
RGD:70332
64345
Horse
hypoxia inducible factor 3 subunit alpha
VGNC:18784
100071095
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hypoxia inducible factor 3 subunit alpha
Macaque
hypoxia inducible factor 3 alpha subunit
Mouse
Rat
Horse
hypoxia inducible factor 3 subunit alpha
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y2N7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (39)
Cellular response to hypoxia (R-HSA-1234174)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to hypoxia
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Developmental Biology
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Cellular response to hypoxia
Cellular responses to external stimuli
Cellular responses to stress
Developmental Biology
Metabolism of proteins
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (110)
1 – 10 of 110
EGLN3
Tclin
Novelty: 0.00643992
Score: 0.976
Data Source: Reactome,STRINGDB
ELOC
Tbio
Novelty: 0.00964847
Score: 0.976
Data Source: Reactome,STRINGDB
EGLN2
Tclin
Novelty: 0.00570785
Score: 0.975
Data Source: Reactome,STRINGDB
VHL
Tchem
Family: Enzyme
Novelty: 0.00285782
Score: 0.974
Data Source: Reactome,STRINGDB
EGLN1
Tclin
Novelty: 0.00236525
Score: 0.973
Data Source: Reactome,STRINGDB
ARNT
Tbio
Family: TF
Novelty: 0.00183071
Score: 0.968
Data Source: Reactome,STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.962
Data Source: Reactome,STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.959
Data Source: Reactome,STRINGDB
ELOB
Tbio
Novelty: 0.01315739
Score: 0.946
Data Source: Reactome,STRINGDB
CA9
Tclin
Family: Enzyme
Novelty: 0.00071546
Score: 0.944
Data Source: STRINGDB
Publication Statistics
PubMed Score  66.18

PubMed score by year
PubTator Score  135.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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