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Tbio
KLHL20
Kelch-like protein 20

Protein Summary
Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubMe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000209884
  • ENSP00000209884
  • ENSG00000076321

Symbol
  • KLEIP
  • KLHLX
  • KHLHX
  • KLEIP
  • KLHLX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor binding site profile
0.85
microRNA
0.74
transcription factor
0.68
histone modification site profile
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.35   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.35   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (364)
SATB2
Tbio
Family:  TF
Novelty:  0.00405935
p_int:  0.999979095
p_ni:  0.000020905
Data Source:  BioPlex
KLHL22
Tbio
Novelty:  0.24456252
p_int:  0.999956603
p_ni:  0.000043397
Score:  0.924
Data Source:  BioPlex,STRINGDB
FBXL17
Tbio
Novelty:  0.16122137
p_int:  0.999877317
p_ni:  0.000122679
p_wrong:  3e-9
Score:  0.154
Data Source:  BioPlex,STRINGDB
FCGR3B
Tbio
Novelty:  0.000429
p_int:  0.999810382
p_ni:  2.7e-8
p_wrong:  0.000189591
Data Source:  BioPlex
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.999486241
p_ni:  0.000513759
Score:  0.983
Data Source:  BioPlex,STRINGDB
NRGN
Tbio
Novelty:  0.00352757
p_int:  0.999209417
p_ni:  0.000757297
p_wrong:  0.000033287
Data Source:  BioPlex
IPP
Tbio
Novelty:  0.12841634
p_int:  0.999176938
p_ni:  0.00082298
p_wrong:  8.2e-8
Score:  0.305
Data Source:  BioPlex,STRINGDB
SPAG7
Tbio
Novelty:  0.05905408
p_int:  0.999173252
p_ni:  0.000826748
Score:  0.197
Data Source:  BioPlex,STRINGDB
PCDHGA5
Tdark
Novelty:  2.13631603
p_int:  0.995879435
p_ni:  0.004120565
Data Source:  BioPlex
CORO7
Tbio
Novelty:  0.14307384
p_int:  0.995736382
p_ni:  0.003654875
p_wrong:  0.000608742
Score:  0.677
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
66
alcohol consumption measurement
3
1
3
56.4
heel bone mineral density
1
1
1
56.2
hemoglobin measurement
2
1
2
54.4
hematocrit
2
1
2
53.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
66
alcohol consumption measurement
3
56.4
heel bone mineral density
1
56.2
hemoglobin measurement
2
54.4
hematocrit
2
53.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 20
VGNC:6899
457525
Macaque
kelch like family member 20
708546
Mouse
MGI:2444855
226541
Rat
RGD:1309490
304920
Dog
kelch like family member 20
VGNC:42455
480067
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 20
Macaque
kelch like family member 20
Mouse
Rat
Dog
kelch like family member 20
Publication Statistics
PubMed Score 10.35
PubMed score by year
PubTator Score 6.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title