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Tbio
FAN1
Fanconi-associated nuclease 1

Protein Summary
Description
Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:2060 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000362065
  • ENSP00000354497
  • ENSG00000198690
  • ENST00000561594
  • ENSP00000455983
  • ENST00000561607
  • ENSP00000454223
  • ENST00000565466
  • ENSP00000454544
  • ENST00000621063
  • ENSP00000484956
  • ENSG00000276787

Symbol
  • KIAA1018
  • MTMR15
  • KMIN
  • hFAN1
  • MTMR15
  • KIAA1018
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
histone modification site profile
0.78
cell type or tissue
0.72
cell line
0.64
virus perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.29   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.29   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Huntington disease
1
1
0
6.4
88.1
age at onset
1
1
0
6.4
88.1
age at onset
1
1
0
6.4
88.1
Huntington disease
1
1
0
6.4
88.1
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Huntington disease
0
6.4
88.1
age at onset
0
6.4
88.1
age at onset
0
6.4
88.1
Huntington disease
0
6.4
88.1
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Name
Explore in Pharos
Explore in Source
DNA Repair
Fanconi Anemia Pathway
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (102)
1 – 10 of 102
MLH1
Tbio
Novelty: 0.00034212
p_int: 1
Score: 0.906
Data Source: BioPlex,STRINGDB
FANCD2
Tbio
Novelty: 0.00316101
Score: 0.99
Data Source: STRINGDB
MUS81
Tbio
Family: Enzyme
Novelty: 0.00532122
Score: 0.988
Data Source: STRINGDB
FANCM
Tbio
Novelty: 0.01122278
Score: 0.986
Data Source: STRINGDB
FANCI
Tbio
Novelty: 0.01223788
Score: 0.984
Data Source: STRINGDB
ERCC4
Tbio
Family: Enzyme
Novelty: 0.01076913
Score: 0.972
Data Source: STRINGDB
DCLRE1A
Tbio
Novelty: 0.0104321
Score: 0.966
Data Source: STRINGDB
FANCL
Tbio
Family: Enzyme
Novelty: 0.00274467
Score: 0.963
Data Source: STRINGDB
SLX4
Tbio
Family: Enzyme
Novelty: 0.01677273
Score: 0.96
Data Source: STRINGDB
DCLRE1B
Tbio
Family: Enzyme
Novelty: 0.0598925
Score: 0.955
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.29

PubMed score by year
PubTator Score  65.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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