Tbio LRCH1 Leucine-rich repeat and calponin homology domain-containing protein 1

Protein Summary

Description

Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration. This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q9Y2L9
• B7ZLL5
• F8W6F0
• Q17R43
• Q2KHR1
• Q5TBU9
• Q7Z5F6
• Q7Z5F7

Gene Name

• LRCH1

Ensembl ID

• ENST00000311191
• ENSP00000308493
• ENSG00000136141
• ENST00000389797
• ENSP00000374447
• ENST00000389798
• ENSP00000374448

Symbol

• CHDC1
• KIAA1016
• NP81
• CHDC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.97
transcription factor binding site profile	0.89
kinase perturbation	0.84
histone modification site profile	0.66
cell line	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.14   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 138   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.14   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0