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Tchem
KDM2A
Lysine-specific demethylase 2A

Protein Summary
Description
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins ar ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398645
  • ENSP00000381640
  • ENSG00000173120
  • ENST00000529006
  • ENSP00000432786
  • ENST00000530342
  • ENSP00000435776

Symbol
  • CXXC8
  • FBL7
  • FBXL11
  • JHDM1A
  • KIAA1004
  • FBL7
  • CXXC8
  • FBL11
  • FBXL11
  • JHDM1A
  • LILINA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor perturbation
0.88
transcription factor
0.85
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.76   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.76   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (18)
1 – 10 of 18
CHEMBL3108958
chemical structure image
CHEMBL2164246
chemical structure image
CHEMBL1229308,CHEMBL1215519
chemical structure image
CHEMBL2164243
chemical structure image
IOX2
chemical structure image
CHEMBL3786265
chemical structure image
CHEMBL3785340
chemical structure image
CHEMBL51979
chemical structure image
CHEMBL3621873
chemical structure image
CHEMBL3786188
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
79.5
body fat distribution
2
1
4
72.2
body height
1
2
2
54.3
prostate carcinoma
1
1
0
1.1
21.2
erythrocyte count
1
1
1
20.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
79.5
body fat distribution
4
72.2
body height
2
54.3
prostate carcinoma
0
1.1
21.2
erythrocyte count
1
20.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 2A
VGNC:7656
107967129
Macaque
lysine demethylase 2A
712907
Mouse
MGI:1354736
225876
Rat
RGD:1309419
361700
Dog
lysine demethylase 2A
VGNC:42320
483702
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 2A
Macaque
lysine demethylase 2A
Mouse
Rat
Dog
lysine demethylase 2A
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HDMs demethylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HDMs demethylate histones
Gene Ontology Terms (8)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (148)
1 – 10 of 148
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.999999986
p_ni: 1.3e-8
Score: 0.987
Data Source: BioPlex,STRINGDB
CGB2
Tdark
Novelty: 0.00598131
p_int: 0.999999227
p_ni: 7.73e-7
Data Source: BioPlex
HIST3H3
Tbio
Novelty: 0.04915012
Score: 0.831
Data Source: STRINGDB
KMT2D
Tbio
Family: Epigenetic
Novelty: 0.00380525
Score: 0.826
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.819
Data Source: STRINGDB
HIST1H4A
Tbio
Novelty: 0.00279614
Score: 0.791
Data Source: STRINGDB
HIST1H4G
Tdark
Novelty: 1.72429907
Score: 0.764
Data Source: STRINGDB
KDM6A
Tchem
Family: Epigenetic
Novelty: 0.00267001
Score: 0.761
Data Source: STRINGDB
HIST1H3A
Tbio
Novelty: 0.00991842
Score: 0.759
Data Source: STRINGDB
HIST2H3A
Tbio
Novelty: 0.02749981
Score: 0.759
Data Source: STRINGDB
Publication Statistics
PubMed Score  55.76

PubMed score by year
PubTator Score  38.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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