Tchem KDM2A Lysine-specific demethylase 2A

Protein Summary

Description

Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• Q9Y2K7
• D4QA03
• E9PIL6
• I3VM55
• Q49A21
• Q4G0M3
• Q69YY8
• Q9BVH5
• Q9H7H5
• Q9UK66

Gene Name

• KDM2A

Ensembl ID

• ENST00000398645
• ENSP00000381640
• ENSG00000173120
• ENST00000529006
• ENSP00000432786
• ENST00000530342
• ENSP00000435776

Symbol

• CXXC8
• FBL7
• FBXL11
• JHDM1A
• KIAA1004
• FBL7
• CXXC8
• FBL11
• FBXL11
• JHDM1A
• LILINA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
transcription factor perturbation	0.88
transcription factor	0.85
ligand (protein) perturbation	0.83
transcription factor binding site profile	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.8   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 243   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.8   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 22

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0