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Tbio
USP20
Ubiquitin carboxyl-terminal hydrolase 20

Protein Summary
Description
Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. This gene encodes a ubiquitin specific processing protease that was first i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315480
  • ENSP00000313811
  • ENSG00000136878
  • ENST00000358355
  • ENSP00000351122
  • ENST00000372429
  • ENSP00000361506

Symbol
  • KIAA1003
  • LSFR3A
  • VDU2
  • VDU2
  • hVDU2
  • LSFR3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
histone modification site profile
0.81
cell line
0.77
molecular function
0.7
virus perturbation
0.64


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.17   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.17   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 20
VGNC:13990
464795
Macaque
ubiquitin specific peptidase 20
716505
Mouse
MGI:1921520
74270
Rat
RGD:1305621
311856
Dog
ubiquitin specific peptidase 20
VGNC:48182
480696
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 20
Macaque
ubiquitin specific peptidase 20
Mouse
Rat
Dog
ubiquitin specific peptidase 20
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y2K6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (77)
1 – 10 of 77
APBA2
Tbio
Novelty: 0.01654185
p_int: 0.999999245
p_ni: 7.54e-7
Score: 0.173
Data Source: BioPlex,STRINGDB
CBX7
Tchem
Family: Epigenetic
Novelty: 0.01612606
p_int: 0.999997127
p_ni: 0.000002868
p_wrong: 5e-9
Score: 0.263
Data Source: BioPlex,STRINGDB
VSX2
Tbio
Family: TF
Novelty: 0.0046733
p_int: 0.999984917
p_ni: 0.000015083
Score: 0.21
Data Source: BioPlex,STRINGDB
VAPA
Tbio
Novelty: 0.00169209
p_int: 0.999892991
p_ni: 0.000107006
p_wrong: 3e-9
Score: 0.197
Data Source: BioPlex,STRINGDB
VAPB
Tbio
Novelty: 0.00542377
p_int: 0.999890338
p_ni: 0.000109592
p_wrong: 7.1e-8
Score: 0.385
Data Source: BioPlex,STRINGDB
TMEM134
Tdark
Novelty: 0.42629221
p_int: 0.999590199
p_ni: 0.000144035
p_wrong: 0.000265766
Data Source: BioPlex
TACR3
Tchem
Family: GPCR
Novelty: 0.00351352
p_int: 0.999330858
p_ni: 0.000127423
p_wrong: 0.000541719
Data Source: BioPlex
DBNL
Tbio
Novelty: 0.03390948
p_int: 0.99923326
p_ni: 0.000500768
p_wrong: 0.000265973
Score: 0.303
Data Source: BioPlex,STRINGDB
CRAMP1
Tdark
Novelty: 0.26519971
p_int: 0.999211361
p_ni: 0.000632585
p_wrong: 0.000156054
Score: 0.208
Data Source: BioPlex,STRINGDB
MAP7D2
Tdark
Novelty: 0.70744439
p_int: 0.99874761
p_ni: 0.000361688
p_wrong: 0.000890701
Score: 0.177
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  18.17

PubMed score by year
PubTator Score  10.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer