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Tdark
R3HDM2
R3H domain-containing protein 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347140
  • ENSP00000317903
  • ENSG00000179912
  • ENST00000358907
  • ENSP00000351784
  • ENST00000441731
  • ENSP00000408536

Symbol
  • KIAA1002
  • CAG6
  • PR01365
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
gene perturbation
0.83
cell type or tissue
0.8
tissue sample
0.67
cell line
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.09   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.09   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
98.7
urate measurement
2
2
1
5.2
96.9
triglyceride measurement
7
4
7
2.7
95.7
testosterone measurement
2
2
2
94
high density lipoprotein cholesterol measurement
5
2
8
85.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
98.7
urate measurement
1
5.2
96.9
triglyceride measurement
7
2.7
95.7
testosterone measurement
2
94
high density lipoprotein cholesterol measurement
8
85.4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919000
71750
Rat
RGD:1310066
362894
Dog
R3H domain containing 2
474412
Horse
R3H domain containing 2
100053125
Cow
R3H domain containing 2
613499
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
R3H domain containing 2
Horse
R3H domain containing 2
Cow
R3H domain containing 2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (44)
1 – 10 of 44
ZSCAN30
Tdark
Family: TF
Novelty: 1.6056338
Score: 0.749
Data Source: STRINGDB
ZNF329
Tdark
Family: TF
Novelty: 2.94784225
Score: 0.724
Data Source: STRINGDB
ECSCR
Tbio
Novelty: 0.11603718
Score: 0.704
Data Source: STRINGDB
PGGHG
Tbio
Family: Enzyme
Novelty: 0.40196205
Score: 0.696
Data Source: STRINGDB
RIPOR1
Tbio
Novelty: 2.88878209
Score: 0.692
Data Source: STRINGDB
INHBC
Tbio
Novelty: 0.06055226
Score: 0.646
Data Source: STRINGDB
TMEM99
Tdark
Novelty: 5.84117773
Score: 0.63
Data Source: STRINGDB
CARMIL1
Tbio
Novelty: 0.04162135
Score: 0.581
Data Source: STRINGDB
C22orf24
Tdark
Novelty: 2.7804878
Score: 0.557
Data Source: STRINGDB
MPRIP
Tbio
Family: Enzyme
Novelty: 0.03253403
Score: 0.553
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.09

PubMed score by year
PubTator Score  8.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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