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Tchem
SIK3
Serine/threonine-protein kinase SIK3

Protein Summary
Description
Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375300
  • ENSP00000364449
  • ENSG00000160584
  • ENST00000446921
  • ENSP00000390442

Symbol
  • KIAA0999
  • QSK
  • L19
  • QSK
  • SEMDK
  • SIK-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
transcription factor perturbation
0.96
co-expressed gene
0.95
molecular function
0.95
protein domain
0.85


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.37   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.37   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
bosutinib
chemical structure image
dasatinib
chemical structure image
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
9
8
9
6.6
98.4
high density lipoprotein cholesterol measurement
3
3
5
97.9
iron biomarker measurement
1
1
1
88.7
total cholesterol measurement
1
1
2
79.5
self reported educational attainment
1
1
1
75.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
9
6.6
98.4
high density lipoprotein cholesterol measurement
5
97.9
iron biomarker measurement
1
88.7
total cholesterol measurement
2
79.5
self reported educational attainment
1
75.7
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SIK family kinase 3
VGNC:1005
451565
Mouse
MGI:2446296
70661
Dog
SIK family kinase 3
VGNC:46171
479426
Horse
SIK family kinase 3
VGNC:22978
100071111
Pig
SIK family kinase 3
100522265
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SIK family kinase 3
Mouse
Dog
SIK family kinase 3
Horse
SIK family kinase 3
Pig
SIK family kinase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y2K2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (42)
1 – 10 of 42
PPP3CC
Tbio
Family: Enzyme
Novelty: 0.02633046
p_int: 0.999999999
p_ni: 1e-9
Score: 0.248
Data Source: BioPlex,STRINGDB
PPP3R2
Tbio
Novelty: 0.01121867
p_int: 0.999996244
p_ni: 0.000003752
p_wrong: 3e-9
Data Source: BioPlex
PPP3CA
Tchem
Family: Enzyme
Novelty: 0.00234189
p_int: 0.999989022
p_ni: 0.000010978
Score: 0.353
Data Source: BioPlex,STRINGDB
SIK1
Tchem
Family: Kinase
Novelty: 0.00523549
p_int: 0.757302989
p_ni: 0.000333229
p_wrong: 0.242363782
Score: 0.494
Data Source: BioPlex,STRINGDB
CRTC2
Tbio
Novelty: 0.01888215
Score: 0.966
Data Source: STRINGDB
CAB39
Tbio
Novelty: 0.01592402
Score: 0.944
Data Source: STRINGDB
YWHAE
Tbio
Novelty: 0.00431876
Score: 0.941
Data Source: STRINGDB
YWHAB
Tchem
Novelty: 0.00614093
Score: 0.941
Data Source: STRINGDB
YWHAH
Tchem
Novelty: 0.01000071
Score: 0.941
Data Source: STRINGDB
YWHAQ
Tchem
Novelty: 0.00234496
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  37.37

PubMed score by year
PubTator Score  9.2

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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