SIK3
Serine/threonine-protein kinase SIK3
Protein Summary
Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling.
- ENST00000375300
- ENSP00000364449
- ENSG00000160584
- ENST00000446921
- ENSP00000390442
- KIAA0999
- QSK
- L19
- QSK
- SEMDK
- SIK-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.97 | ||
transcription factor perturbation | 0.96 | ||
co-expressed gene | 0.95 | ||
molecular function | 0.95 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.9 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.9 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 8
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2