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Tchem
SIK3
Serine/threonine-protein kinase SIK3

Protein Summary
Description
Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375300
  • ENSP00000364449
  • ENSG00000160584
  • ENST00000446921
  • ENSP00000390442

Symbol
  • KIAA0999
  • QSK
  • L19
  • QSK
  • SEMDK
  • SIK-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
transcription factor perturbation
0.96
co-expressed gene
0.95
molecular function
0.95
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.9   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.9   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2