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Tchem
PADI2
Protein-arginine deiminase type-2

Protein Summary
Description
Catalyzes the deimination of arginine residues of proteins. This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375481
  • ENSP00000364630
  • ENSG00000117115
  • ENST00000375486
  • ENSP00000364635

Symbol
  • KIAA0994
  • PAD2
  • PDI2
  • PAD2
  • PDI2
  • PAD-H19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
disease perturbation
0.93
biological process
0.9
protein domain
0.73
PubMedID
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.46   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.46   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
77.8
hematocrit
1
1
1
66.9
1
1
1
33.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
77.8
hematocrit
1
66.9
1
33.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidyl arginine deiminase 2
VGNC:10030
456527
Macaque
peptidyl arginine deiminase 2
711044
Mouse
MGI:1338892
18600
Rat
RGD:3288
29511
Dog
peptidyl arginine deiminase 2
VGNC:44235
487414
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidyl arginine deiminase 2
Macaque
peptidyl arginine deiminase 2
Mouse
Rat
Dog
peptidyl arginine deiminase 2
Protein Data Bank (19)
1 – 5 of 19
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Immune System
Innate Immune System
Neutrophil degranulation
Protein-Protein Interactions (122)
1 – 10 of 122
PRTN3
Tchem
Family: Enzyme
Novelty: 0.00022728
Score: 0.961
Data Source: STRINGDB
MPO
Tchem
Family: Enzyme
Novelty: 0.00020698
Score: 0.923
Data Source: STRINGDB
ELANE
Tclin
Family: Enzyme
Novelty: 0.00026112
Score: 0.916
Data Source: STRINGDB
CTSG
Tchem
Family: Enzyme
Novelty: 0.00102052
Score: 0.91
Data Source: STRINGDB
HRNR
Tbio
Novelty: 0.0316035
Score: 0.909
Data Source: STRINGDB
MNDA
Tbio
Novelty: 0.01991479
Score: 0.907
Data Source: STRINGDB
TTR
Tclin
Novelty: 0.0001199
Score: 0.906
Data Source: STRINGDB
RNASE2
Tchem
Family: Enzyme
Novelty: 0.00267471
Score: 0.905
Data Source: STRINGDB
PLAC8
Tbio
Novelty: 0.00882894
Score: 0.905
Data Source: STRINGDB
AZU1
Tbio
Family: Enzyme
Novelty: 0.00267169
Score: 0.905
Data Source: STRINGDB
Publication Statistics
PubMed Score  227.46

PubMed score by year
PubTator Score  130.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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