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Tbio
AMOTL2
Angiomotin-like protein 2

Protein Summary
Description
Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249883
  • ENSP00000249883
  • ENSG00000114019
  • ENST00000422605
  • ENSP00000409999
  • ENST00000513145
  • ENSP00000425475
  • ENST00000514516
  • ENSP00000424765

Symbol
  • KIAA0989
  • LCCP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
kinase perturbation
0.88
PubMedID
0.86
transcription factor binding site profile
0.8
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.86   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.86   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
MPP5
Tbio
Novelty:  0.01707773
p_int:  0.999999982
p_ni:  8e-9
p_wrong:  9e-9
Score:  0.605
Data Source:  BioPlex,STRINGDB
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.999913559
p_ni:  0.000085005
p_wrong:  0.000001436
Data Source:  BioPlex
HTATIP2
Tbio
Family:  Enzyme
Novelty:  0.01940704
p_int:  0.999819993
p_ni:  0.000179956
p_wrong:  5.1e-8
Score:  0.54
Data Source:  BioPlex,STRINGDB
LATS2
Tchem
Family:  Kinase
Novelty:  0.00521035
Score:  0.985
Data Source:  STRINGDB
YAP1
Tchem
Novelty:  0.00124225
Score:  0.981
Data Source:  Reactome,STRINGDB
LATS1
Tchem
Family:  Kinase
Novelty:  0.00369058
Score:  0.964
Data Source:  STRINGDB
WWTR1
Tbio
Novelty:  0.00431186
Score:  0.959
Data Source:  Reactome,STRINGDB
MOB1A
Tbio
Family:  Enzyme
Novelty:  0.01430129
Score:  0.942
Data Source:  STRINGDB
SAV1
Tbio
Novelty:  0.00962335
Score:  0.941
Data Source:  STRINGDB
YWHAB
Tchem
Novelty:  0.00614093
Score:  0.924
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Hippo
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Hippo
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
1
2
47.7
Myopia
1
1
0
6.1
35
refractive error measurement
1
1
0
6.1
35
age at onset
1
1
0
6.1
35
reticulocyte count
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
47.7
Myopia
0
6.1
35
refractive error measurement
0
6.1
35
age at onset
0
6.1
35
reticulocyte count
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
angiomotin like 2
VGNC:1731
460712
Mouse
MGI:1929286
56332
Rat
RGD:70977
65157
Dog
angiomotin like 2
VGNC:37837
485669
Horse
angiomotin like 2
VGNC:15282
100053062
Species
Name
OMA
EggNOG
Inparanoid
Chimp
angiomotin like 2
Mouse
Rat
Dog
angiomotin like 2
Horse
angiomotin like 2
Publication Statistics
PubMed Score 25.86
PubMed score by year
PubTator Score 12.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title