Tbio EPB41L3 Band 4.1-like protein 3

Protein Summary

Description

Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5.

Uniprot Accession IDs

• Q9Y2J2
• B7Z4I5
• F5GX05
• O95713
• Q9BRP5

Gene Name

• EPB41L3

Ensembl ID

• ENST00000341928
• ENSP00000343158
• ENSG00000082397
• ENST00000540638
• ENSP00000442091
• ENST00000544123
• ENSP00000441174

Symbol

• DAL1
• KIAA0987
• 4.1B
• DAL1
• DAL-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
transcription factor perturbation	0.98
hub protein	0.95
interacting protein	0.95
gene perturbation	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.18   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 228   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.18   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0