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Tbio
EPB41L3
Band 4.1-like protein 3

Protein Summary
Description
Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341928
  • ENSP00000343158
  • ENSG00000082397
  • ENST00000540638
  • ENSP00000442091
  • ENST00000544123
  • ENSP00000441174

Symbol
  • DAL1
  • KIAA0987
  • 4.1B
  • DAL1
  • DAL-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.98
hub protein
0.95
interacting protein
0.95
gene perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.5   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.5   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (150)
1 – 10 of 150
AP3M2
Tbio
Novelty:  0.18164255
p_int:  0.999999901
p_ni:  9.9e-8
Data Source:  BioPlex
AP3B2
Tbio
Novelty:  0.11897342
p_int:  0.999999694
p_ni:  3.06e-7
Data Source:  BioPlex
NACAD
Tdark
Novelty:  0.46197991
p_int:  0.999999425
p_ni:  2.84e-7
p_wrong:  2.91e-7
Data Source:  BioPlex
AGAP1
Tbio
Family:  Enzyme
Novelty:  0.06776705
p_int:  0.999999104
p_ni:  8.96e-7
Data Source:  BioPlex
AP3B1
Tbio
Novelty:  0.03117931
p_int:  0.999998888
p_ni:  0.000001112
Data Source:  BioPlex
AP3M1
Tbio
Novelty:  0.5036622
p_int:  0.999998815
p_ni:  0.000001185
Data Source:  BioPlex
MLLT3
Tchem
Novelty:  0.00361056
p_int:  0.999996778
p_ni:  0.000003222
Data Source:  BioPlex
RIOK1
Tchem
Family:  Kinase
Novelty:  0.02476698
p_int:  0.999995974
p_ni:  0.000004026
Data Source:  BioPlex
RNPS1
Tbio
Novelty:  0.03203224
p_int:  0.999992622
p_ni:  0.000007378
Data Source:  BioPlex
CWC22
Tbio
Novelty:  0.027689
p_int:  0.99999198
p_ni:  0.00000802
Data Source:  BioPlex
Pathways (8)
Neurexins and neuroligins (R-HSA-6794361)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Gene Ontology Terms (23)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
5
4
5
7.5
92.4
creatinine measurement
1
1
1
27.3
urate measurement
1
1
1
26.1
stroke
1
1
0
1.2
3.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
5
7.5
92.4
creatinine measurement
1
27.3
urate measurement
1
26.1
stroke
0
1.2
3.6
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
erythrocyte membrane protein band 4.1 like 3
VGNC:9911
455309
Macaque
band 4.1-like protein 3
693475
Mouse
MGI:103008
13823
Rat
RGD:71089
116724
Dog
erythrocyte membrane protein band 4.1 like 3
VGNC:40395
480198
Species
Name
OMA
EggNOG
Inparanoid
Chimp
erythrocyte membrane protein band 4.1 like 3
Macaque
band 4.1-like protein 3
Mouse
Rat
Dog
erythrocyte membrane protein band 4.1 like 3
Publication Statistics
PubMed Score 86.50
PubMed score by year
PubTator Score 58.42
PubTator score by year