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Tbio
EPB41L3
Band 4.1-like protein 3

Protein Summary
Description
Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341928
  • ENSP00000343158
  • ENSG00000082397
  • ENST00000540638
  • ENSP00000442091
  • ENST00000544123
  • ENSP00000441174

Symbol
  • DAL1
  • KIAA0987
  • 4.1B
  • DAL1
  • DAL-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.98
hub protein
0.95
interacting protein
0.95
gene perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.18   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.18   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Neurexins and neuroligins (R-HSA-6794361)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Gene Ontology Terms (23)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (150)
1 – 10 of 150
AP3M2
Tbio
Novelty: 0.21081081
p_int: 0.999999901
p_ni: 9.9e-8
Data Source: BioPlex
AP3B2
Tbio
Novelty: 0.16013821
p_int: 0.999999694
p_ni: 3.06e-7
Data Source: BioPlex
NACAD
Tbio
Novelty: 0.12765957
p_int: 0.999999425
p_ni: 2.84e-7
p_wrong: 2.91e-7
Data Source: BioPlex
AGAP1
Tbio
Family: Enzyme
Novelty: 0.12870216
p_int: 0.999999104
p_ni: 8.96e-7
Data Source: BioPlex
AP3B1
Tbio
Novelty: 0.05716867
p_int: 0.999998888
p_ni: 0.000001112
Data Source: BioPlex
AP3M1
Tbio
Novelty: 1
p_int: 0.999998815
p_ni: 0.000001185
Data Source: BioPlex
MLLT3
Tbio
Novelty: 0.00455431
p_int: 0.999996778
p_ni: 0.000003222
Data Source: BioPlex
RIOK1
Tchem
Family: Kinase
Novelty: 0.02653076
p_int: 0.999995974
p_ni: 0.000004026
Data Source: BioPlex
RNPS1
Tbio
Novelty: 0.03863535
p_int: 0.999992622
p_ni: 0.000007378
Data Source: BioPlex
CWC22
Tbio
Novelty: 0.00359581
p_int: 0.99999198
p_ni: 0.00000802
Data Source: BioPlex
Publication Statistics
PubMed Score  128.18

PubMed score by year
PubTator Score  58.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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