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Tbio
TBC1D30
TBC1 domain family member 30

Protein Summary
Description
GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000539867
  • ENSP00000440207
  • ENSG00000111490

Symbol
  • KIAA0984
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.72
microRNA
0.68
cell line
0.52
molecular function
0.49
tissue sample
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.52   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.52   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insulin measurement
1
1
1
67.1
FEV/FEC ratio
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insulin measurement
1
67.1
FEV/FEC ratio
1
38.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 30
VGNC:13466
467055
Macaque
TBC1 domain family member 30
717527
Mouse
MGI:1921944
74694
Rat
RGD:1305255
299824
Dog
TBC1 domain family member 30
VGNC:47146
481147
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 30
Macaque
TBC1 domain family member 30
Mouse
Rat
Dog
TBC1 domain family member 30
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y2I9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (75)
1 – 10 of 75
SCOC
Tbio
Novelty:  0.05277646
p_int:  0.999999938
p_ni:  4.1e-8
p_wrong:  2.1e-8
Score:  0.297
Data Source:  BioPlex,STRINGDB
TBC1D7
Tbio
Novelty:  0.06502242
Score:  0.761
Data Source:  STRINGDB
PPFIA2
Tbio
Novelty:  0.13312014
Score:  0.731
Data Source:  STRINGDB
SPATA25
Tbio
Novelty:  0.80142563
Score:  0.724
Data Source:  STRINGDB
IRAK1BP1
Tbio
Family:  Enzyme
Novelty:  0.02320965
Score:  0.717
Data Source:  STRINGDB
NEURL2
Tdark
Novelty:  0.29029379
Score:  0.713
Data Source:  STRINGDB
PHIP
Tbio
Family:  Epigenetic
Novelty:  0.02496083
Score:  0.695
Data Source:  STRINGDB
CFAP61
Tdark
Novelty:  0.58493403
Score:  0.645
Data Source:  STRINGDB
DNAAF4
Tbio
Novelty:  0.01730685
Score:  0.637
Data Source:  STRINGDB
RAB17
Tbio
Family:  Enzyme
Novelty:  0.04352198
Score:  0.634
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.52

PubMed score by year
PubTator Score  0.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer