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Tchem
PIKFYVE
1-phosphatidylinositol 3-phosphate 5-kinase

Protein Summary
Description
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes. Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylino ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264380
  • ENSP00000264380
  • ENSG00000115020
  • ENST00000308862
  • ENSP00000308715
  • ENST00000392202
  • ENSP00000376038
  • ENST00000407449
  • ENSP00000384356

Symbol
  • KIAA0981
  • PIP5K3
  • CFD
  • FAB1
  • HEL37
  • PIP5K
  • PIP5K3
  • ZFYVE29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
transcription factor binding site profile
0.88
microRNA
0.84
cell line
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 254.99   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 304   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 254.99   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 304   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (1)
1 – 1 of 1
apilimod
Rendered image for apilimod
Protein-Protein Interactions (186)
1 – 10 of 186
FIG4
Tbio
Family:  Enzyme
Novelty:  0.00742268
p_int:  0.99999905
p_ni:  9.5e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
VAC14
Tbio
Novelty:  0.02677738
p_int:  0.999998328
p_ni:  0.000001662
p_wrong:  1e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ANK1
Tbio
Novelty:  0.00225305
p_int:  0.999957701
p_ni:  0.000042299
Score:  0.867
Data Source:  BioPlex,STRINGDB
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.999874088
p_ni:  0.000125912
Data Source:  BioPlex
TIMM23
Tbio
Family:  Enzyme
Novelty:  0.06463808
p_int:  0.84013223
p_ni:  0.159746701
p_wrong:  0.00012107
Score:  0.197
Data Source:  BioPlex,STRINGDB
PIK3C3
Tchem
Family:  Kinase
Novelty:  0.00269825
Score:  0.989
Data Source:  STRINGDB
PIK3R4
Tbio
Family:  Kinase
Novelty:  0.01412698
Score:  0.98
Data Source:  STRINGDB
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
Score:  0.975
Data Source:  STRINGDB
SACM1L
Tbio
Family:  Enzyme
Novelty:  0.00499867
Score:  0.974
Data Source:  STRINGDB
PI4KB
Tchem
Family:  Kinase
Novelty:  0.00856875
Score:  0.97
Data Source:  STRINGDB
Pathways (14)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the Golgi membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the Golgi membrane
Gene Ontology Terms (21)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
HGNC
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
42.3
1
1
0
1.2
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
42.3
0
1.2
42.3
Find similar targets by:
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoinositide kinase, FYVE-type zinc finger containing
VGNC:2754
459908
Macaque
phosphoinositide kinase, FYVE-type zinc finger containing
710115
Mouse
MGI:1335106
18711
Rat
RGD:1592067
316457
Dog
phosphoinositide kinase, FYVE-type zinc finger containing
VGNC:44564
478890
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoinositide kinase, FYVE-type zinc finger containing
Macaque
phosphoinositide kinase, FYVE-type zinc finger containing
Mouse
Rat
Dog
phosphoinositide kinase, FYVE-type zinc finger containing
Publication Statistics
PubMed Score 254.99
PubMed score by year
PubTator Score 83.50
PubTator score by year
Patents
Patents by year