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Tbio
NINL
Ninein-like protein

Protein Summary
Description
Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278886
  • ENSP00000278886
  • ENSG00000101004
  • ENST00000422516
  • ENSP00000410431

Symbol
  • KIAA0980
  • NLP
  • NLP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
gene perturbation
0.74
virus perturbation
0.72
cell line
0.66
transcription factor
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.69   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.69   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking initiation
1
1
1
82.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking initiation
1
82.6
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ninein like
VGNC:6212
458148
Macaque
ninein like
706257
Mouse
MGI:1925427
78177
Rat
RGD:1306152
311529
Dog
ninein like
VGNC:43813
477006
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ninein like
Macaque
ninein like
Mouse
Rat
Dog
ninein like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y2I6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (150)
1 – 10 of 150
FAM9C
Tdark
Novelty: 0.86727989
p_int: 0.99999999
p_ni: 9e-9
p_wrong: 1e-9
Data Source: BioPlex
RGS2
Tbio
Novelty: 0.00370571
p_int: 0.999999976
p_ni: 1.7e-8
p_wrong: 7e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
LRRC39
Tdark
Novelty: 0.70657884
p_int: 0.999999875
p_ni: 1.24e-7
Score: 0.519
Data Source: BioPlex,STRINGDB
ZNF408
Tbio
Family: TF
Novelty: 0.10649477
p_int: 0.999999535
p_ni: 4.61e-7
p_wrong: 4e-9
Data Source: BioPlex
CCDC172
Tdark
Novelty: 4.18978102
p_int: 0.999995778
p_ni: 0.000004222
Score: 0.214
Data Source: BioPlex,STRINGDB
MRPS34
Tbio
Novelty: 0.29355603
p_int: 0.999989217
p_ni: 0.000010774
p_wrong: 9e-9
Data Source: BioPlex
NKAP
Tbio
Novelty: 0.04982584
p_int: 0.999694167
p_ni: 0.000295559
p_wrong: 0.000010274
Data Source: BioPlex
TPM2
Tbio
Novelty: 0.00406572
p_int: 0.849087416
p_ni: 0.136816387
p_wrong: 0.014096198
Data Source: BioPlex
PLK1
Tchem
Family: Kinase
Novelty: 0.00062799
Score: 0.978
Data Source: STRINGDB
TUBG1
Tbio
Novelty: 0.02252882
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score  138.69

PubMed score by year
PubTator Score  169.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer