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Tbio
NTNG1
Netrin-G1

Protein Summary
Description
Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites. This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370065
  • ENSP00000359082
  • ENSG00000162631
  • ENST00000370066
  • ENSP00000359083
  • ENST00000370067
  • ENSP00000359084
  • ENST00000370068
  • ENSP00000359085
  • ENST00000370071
  • ENSP00000359088
  • ENST00000370073
  • ENSP00000359090
  • ENST00000370074
  • ENSP00000359091

Symbol
  • KIAA0976
  • LMNT1
  • Lmnt1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.75
PubMedID
0.7
transcription factor
0.7
disease
0.6
kinase perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.09   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.09   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
96.3
testosterone measurement
3
3
3
91.9
body mass index
3
4
4
70.5
serum gamma-glutamyl transferase measurement
2
2
2
70.5
bilirubin measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
96.3
testosterone measurement
3
91.9
body mass index
4
70.5
serum gamma-glutamyl transferase measurement
2
70.5
bilirubin measurement
1
44.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
netrin G1
VGNC:1421
457074
Macaque
netrin G1
694410
Mouse
MGI:1934028
80883
Dog
netrin G1 [Source:HGNC Symbol;Acc:HGNC:23319]
Horse
netrin G1
VGNC:20925
100060362
Species
Name
OMA
EggNOG
Inparanoid
Chimp
netrin G1
Macaque
netrin G1
Mouse
Dog
netrin G1 [Source:HGNC Symbol;Acc:HGNC:23319]
Horse
netrin G1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y2I2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
SynGO-UCL
Inferred from Genetic Interaction (IGI)
SynGO-UCL
Protein-Protein Interactions (154)
1 – 10 of 154
HSPA6
Tbio
Novelty:  0.00654285
p_int:  0.851978578
p_ni:  0.148021422
Score:  0.309
Data Source:  BioPlex,STRINGDB
GAS6
Tbio
Novelty:  0.00297606
p_int:  0.85191461
p_ni:  0.148085302
p_wrong:  8.8e-8
Score:  0.229
Data Source:  BioPlex,STRINGDB
LRRC4C
Tbio
Novelty:  0.06534005
Score:  0.988
Data Source:  STRINGDB
MDGA1
Tbio
Novelty:  0.04478487
Score:  0.943
Data Source:  STRINGDB
CNTN3
Tbio
Novelty:  0.0055725
Score:  0.93
Data Source:  STRINGDB
CNTN4
Tbio
Novelty:  0.02483465
Score:  0.927
Data Source:  STRINGDB
NEGR1
Tbio
Novelty:  0.0088917
Score:  0.923
Data Source:  STRINGDB
OPCML
Tbio
Novelty:  0.01569352
Score:  0.92
Data Source:  STRINGDB
RTN4RL1
Tbio
Novelty:  0.07113722
Score:  0.919
Data Source:  STRINGDB
NTM
Tbio
Novelty:  0.01659865
Score:  0.918
Data Source:  STRINGDB
Publication Statistics
PubMed Score  21.09

PubMed score by year
PubTator Score  23.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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