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Tclin
NISCH
Nischarin

Protein Summary
Description
Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345716
  • ENSP00000339958
  • ENSG00000010322
  • ENST00000420808
  • ENSP00000392484
  • ENST00000479054
  • ENSP00000418232

Symbol
  • IRAS
  • KIAA0975
  • I-1
  • IR1
  • IRAS
  • hIRAS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
transcription factor perturbation
0.94
disease perturbation
0.74
molecular function
0.73
drug perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 769.62   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 769.62   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 134
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8
Active Ligands (134)
1 – 10 of 134
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
3
3
93
high density lipoprotein cholesterol measurement
5
5
7
91.9
waist-hip ratio
4
13
15
91.4
BMI-adjusted waist-hip ratio
10
15
24
91.1
hematocrit
3
2
3
88.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
93
high density lipoprotein cholesterol measurement
7
91.9
waist-hip ratio
15
91.4
BMI-adjusted waist-hip ratio
24
91.1
hematocrit
3
88.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nischarin
VGNC:2446
745886
Macaque
nischarin
696916
Mouse
MGI:1928323
64652
Rat
RGD:1306950
306255
Dog
nischarin
VGNC:43822
100855697
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nischarin
Macaque
nischarin
Mouse
Rat
Dog
nischarin
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y2I1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (70)
1 – 10 of 70
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.962214647
p_ni:  0.037785353
Score:  0.288
Data Source:  BioPlex,STRINGDB
PIK3R3
Tbio
Family:  Enzyme
Novelty:  0.0136069
p_int:  0.954706713
p_ni:  0.045293285
p_wrong:  2e-9
Score:  0.6
Data Source:  BioPlex,STRINGDB
CNKSR3
Tbio
Family:  Enzyme
Novelty:  0.14999986
p_int:  0.881926924
p_ni:  0.118073076
Score:  0.679
Data Source:  BioPlex,STRINGDB
UBE2M
Tchem
Novelty:  0.02353106
p_int:  0.870763572
p_ni:  0.129236428
Score:  0.249
Data Source:  BioPlex,STRINGDB
CSNK1G2
Tchem
Family:  Kinase
Novelty:  0.17930147
p_int:  0.840805742
p_ni:  0.159194258
Score:  0.189
Data Source:  BioPlex,STRINGDB
ODAM
Tbio
Novelty:  0.01922413
p_int:  0.810659197
p_ni:  0.189340803
Score:  0.252
Data Source:  BioPlex,STRINGDB
UNC119
Tchem
Novelty:  0.00396292
p_int:  0.792166069
p_ni:  0.207833931
Data Source:  BioPlex
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.757974182
p_ni:  0.242025818
Data Source:  BioPlex
NR1H4
Tclin
Family:  NR
Novelty:  0.00067092
Score:  0.793
Data Source:  STRINGDB
ITGA5
Tbio
Novelty:  0.00285802
Score:  0.71
Data Source:  STRINGDB
Publication Statistics
PubMed Score  769.62

PubMed score by year
PubTator Score  272.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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