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Tchem
MAST1
Microtubule-associated serine/threonine-protein kinase 1

Protein Classes
Protein Summary
Description
Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). This gene is a member of the microtubule-associated serine/threonine kinase (MAST) family. The protein encoded by this gene has an N-terminal serine/threonine kinase domain followed by a postsynaptic density protein-95/discs large/zona occludens-1 (PDZ) domain. In mouse and rat, the orthologous protein associates with the cytoskeleton and can bind both beta-2-syntrophin and neuronal nitric oxide synthase (nNOS) through its PDZ domain. In mouse and rat, this protein also co-localizes with dystrophin- and utrophin-associated protein complexes (DAPC/UAPC) in the vascular endothelium of the central nervous system. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251472
  • ENSP00000251472
  • ENSG00000105613

Symbol
  • KIAA0973
  • SAST
  • SAST
  • MCCCHCM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.95
virus perturbation
0.72
tissue sample
0.71
transcription factor binding site profile
0.63


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.95   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.95   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL603469
chemical structure image
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
92
mean corpuscular volume
2
2
2
86.9
red blood cell distribution width
2
1
2
84.3
mean corpuscular hemoglobin concentration
1
1
1
80.1
cognitive function measurement
1
1
1
79.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
92
mean corpuscular volume
2
86.9
red blood cell distribution width
2
84.3
mean corpuscular hemoglobin concentration
1
80.1
cognitive function measurement
1
79.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microtubule associated serine/threonine kinase 1
VGNC:7539
456367
Mouse
MGI:1861901
56527
Rat
RGD:631372
353118
Dog
microtubule associated serine/threonine kinase 1
VGNC:43032
100682579
Horse
microtubule associated serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:19034]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microtubule associated serine/threonine kinase 1
Mouse
Rat
Dog
microtubule associated serine/threonine kinase 1
Horse
microtubule associated serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:19034]
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y2H9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (61)
1 – 10 of 61
PTEN
Tchem
Family: Enzyme
Novelty: 0.00013818
Score: 0.784
Data Source: STRINGDB
MAGI2
Tbio
Family: Enzyme
Novelty: 0.01674725
Score: 0.74
Data Source: STRINGDB
S100B
Tchem
Novelty: 0.00031007
Score: 0.723
Data Source: STRINGDB
FRYL
Tdark
Novelty: 0.13893531
Score: 0.63
Data Source: STRINGDB
FRY
Tbio
Novelty: 0.14352873
Score: 0.63
Data Source: STRINGDB
JADE2
Tbio
Family: Epigenetic
Novelty: 0.19820849
Score: 0.595
Data Source: STRINGDB
PLK5
Tbio
Family: Kinase
Novelty: 0.14570331
Score: 0.586
Data Source: STRINGDB
PPP2R2C
Tbio
Family: Enzyme
Novelty: 0.05453128
Score: 0.584
Data Source: STRINGDB
PPP2R2B
Tbio
Family: Enzyme
Novelty: 0.01200339
Score: 0.582
Data Source: STRINGDB
ELAVL4
Tbio
Novelty: 0.00260383
Score: 0.579
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.95

PubMed score by year
PubTator Score  18.73

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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