Tchem MAST1 Microtubule-associated serine/threonine-protein kinase 1

Protein Summary

Description

Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity). This gene is a member of the microtubule-associated serine/threonine kinase (MAST) family. The protein encoded by this gene has an N-terminal serine/threonine kinase domain followed by a postsynaptic density protein-95/discs large/zona occludens-1 (PDZ) domain. In mouse and rat, the orthologous protein associates with the cytoskeleton and can bind both beta-2-syntrophin and neuronal nitric oxide synthase (nNOS) through its PDZ domain. In mouse and rat, this protein also co-localizes with dystrophin- and utrophin-associated protein complexes (DAPC/UAPC) in the vascular endothelium of the central nervous system. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• Q9Y2H9
• O00114
• Q8N6X0

Gene Name

• MAST1

Ensembl ID

• ENST00000251472
• ENSP00000251472
• ENSG00000105613

Symbol

• KIAA0973
• SAST
• SAST
• MCCCHCM

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
molecular function	0.95
virus perturbation	0.72
tissue sample	0.71
transcription factor binding site profile	0.63

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Microtubule-associated Serine/threonine-protein Kinase 1

Protein / Transfer/carrier Protein / Microtubule-associated Serine/threonine-protein Kinase 1

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Microtubule-associated Serine/threonine-protein Kinase 1

Protein / Calcium-binding Protein / Annexin / Microtubule-associated Serine/threonine-protein Kinase 1

DTO Classes

Protein / Kinase / Protein Kinase / Agc Group / Mast Family / Microtubule-associated Serine/threonine-protein Kinase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.1   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 82   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.1   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0