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Tbio
SBNO2
Protein strawberry notch homolog 2

Protein Summary
Description
Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages (PubMed:18025162). Plays a role as a regulator in the proinflammatory cascade (PubMed:18025162).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361757
  • ENSP00000354733
  • ENSG00000064932
  • ENST00000438103
  • ENSP00000400762
  • ENST00000612198
  • ENSP00000477651
  • ENSG00000278788
  • ENST00000622719
  • ENSP00000482802
  • ENST00000631948
  • ENSP00000488808

Symbol
  • KIAA0963
  • SNO
  • STNO
  • KIAA0963
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.84
biological process
0.78
transcription factor binding site profile
0.76
virus perturbation
0.76
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.93   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.93   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
6
97.5
3
2
0
1.2
91.3
sex hormone-binding globulin measurement
3
1
3
84.8
reticulocyte count
7
2
7
76.7
1
1
0
1.1
75.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
97.5
0
1.2
91.3
sex hormone-binding globulin measurement
3
84.8
reticulocyte count
7
76.7
0
1.1
75.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
strawberry notch homolog 2
VGNC:13662
455542
Macaque
strawberry notch homolog 2
721186
Mouse
MGI:2448490
216161
Rat
RGD:1307194
314619
Dog
strawberry notch homolog 2
VGNC:45885
485089
Species
Name
OMA
EggNOG
Inparanoid
Chimp
strawberry notch homolog 2
Macaque
strawberry notch homolog 2
Mouse
Rat
Dog
strawberry notch homolog 2
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (24)
1 – 10 of 24
BCL3
Tbio
Novelty: 0.04037329
Score: 0.691
Data Source: STRINGDB
ETV3
Tbio
Family: TF
Novelty: 0.05215391
Score: 0.69
Data Source: STRINGDB
NOL8
Tbio
Novelty: 0.28065454
Score: 0.64
Data Source: STRINGDB
MIDN
Tbio
Novelty: 0.0730514
Score: 0.612
Data Source: STRINGDB
C19orf24
Tdark
Novelty: 0.72451174
Score: 0.571
Data Source: STRINGDB
MAMLD1
Tbio
Novelty: 0.01681081
Score: 0.565
Data Source: STRINGDB
DCSTAMP
Tbio
Novelty: 0.01107838
Score: 0.491
Data Source: STRINGDB
R3HDM4
Tdark
Novelty: 7.43661972
Score: 0.484
Data Source: STRINGDB
KANSL1
Tbio
Novelty: 0.03032662
Score: 0.481
Data Source: STRINGDB
GPR83
Tchem
Family: GPCR
Novelty: 0.03554942
Score: 0.479
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.93

PubMed score by year
PubTator Score  169.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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